Campylobacter jejuni capsule types in a Peruvian birth cohort and associations with diarrhoeal disease severity

Britney Neitenbach, Frédéric Poly, Janelle Kuroiwa, Rosa Burga, Maribel Paredes Olortegui, Patricia Guerry, Margaret Kosek, Chad K. Porter*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Campylobacter jejuni is a leading cause of bacterial diarrhoea worldwide. The objective of this study was to examine the association between C. jejuni capsule types and clinical signs and symptoms of diarrhoeal disease in a well-defined birth cohort in Peru. Children were enrolled in the study at birth and followed until 2 years of age as part of the Malnutrition and Enteric Infections birth cohort. Associations between capsule type and clinical outcomes were assessed using the Pearson’s χ2 and the Kruskal–Wallis test statistics. A total of 318 C. jejuni samples (30% from symptomatic cases) were included in this analysis. There were 22 different C. jejuni capsule types identified with five accounting for 49.1% of all isolates. The most common capsule types among the total number of isolates were HS4 complex (n = 52, 14.8%), HS5/31 complex (n = 42, 11.9%), HS15 (n = 29, 8.2%), HS2 (n = 26, 7.4%) and HS10 (n = 24, 6.8%). These five capsule types accounted for the majority of C. jejuni infections; however, there was no significant difference in prevalence between symptomatic and asymptomatic infection (all p > 0.05). The majority of isolates (n = 291, 82.7%) were predicted to express a heptose-containing capsule. The predicted presence of methyl phosphoramidate, heptose or deoxyheptose on the capsule was common.

Original languageEnglish
Article numbere149
JournalEpidemiology and Infection
Volume147
DOIs
StatePublished - 2019
Externally publishedYes

Keywords

  • Campylobacter jejuni
  • Capsule types
  • Multiplex PCR
  • Paediatric enteric disease
  • Vaccine development

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