Cancer proteomics: The state of the art

Paul C. Herrmann, Lance A. Liotta, Emanuel F. Petricoin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Now that the human genome has been determined, the field of proteomics is ramping up to tackle the vast protein networks that both control and are controlled by the information encoded by the genome. The study of proteomics should yield an unparalleled understanding of cancer as well as an invaluable new target for therapeutic intervention and markers for early detection. This rapidly expanding field attempts to track the protein interactions responsible for all cellular processes. By careful analysis of these systems, a detailed understanding of the molecular causes and consequences of cancer should emerge. A brief overview of some of the cutting edge technologies employed by this rapidly expanding field is given, along with specific examples of how these technologies are employed. Soon cellular protein networks will be understood at a level that will permit a totally new paradigm of diagnosis and will allow therapy tailored to individual patients and situations.

Original languageEnglish
Pages (from-to)49-57
Number of pages9
JournalDisease Markers
Issue number2
StatePublished - 2001
Externally publishedYes


  • Cancer
  • Laser capture microdissection
  • Proteomics
  • Signal transduction


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