Cardiovascular consequences of polycystic ovary syndrome

L. L. Amowitz, B. E. Sobel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Polycystic ovary syndrome (PCOS), a syndrome of hyperandrogenism and anovulation with numerous associated derangements, is typified by a substantially increased incidence of type 2 diabetes mellitus and coronary disease in mid-adult life. A marker of the disorder, and a potential determinant of the macroangiopathy, is insulin resistance. Thus, in addition to altered lipid metabolism, hypertension, hormonal derangements, obesity, and altered coagulation - all of which may contribute to the development of vascular disease - the insulin resistance and dysinsulinemia may underlie impaired fibrinolysis and related derangements within the vessel walls that may be modifiable by attenuation of insulin resistance and amelioration of hyperinsulinemia.

Original languageEnglish
Pages (from-to)439-458
Number of pages20
JournalEndocrinology and Metabolism Clinics of North America
Issue number2
StatePublished - 1999
Externally publishedYes


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