Cardiovascular-related outcomes in U.S. adults exposed to lead

Emmanuel Obeng-Gyasi*, Rodrigo X. Armijos, M. Margaret Weigel, Gabriel M. Filippelli, M. Aaron Sayegh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Cardiovascular-related clinical markers were evaluated in this cross-sectional study of United States adults (aged ≥ 20) exposed to lead via the National Health and Nutrition Examination Survey 2007-2008 and the 2009-2010 datasets. In four quartiles of exposure-0-2 µg/dL, 2-5 µg/dL, 5-10 µg/dL, and 10 µg/dL and over, clinical and anthropometric markers were evaluated-to examine how the markers manifested in the quartiles. Associations were determined via linear regression. Finally, clinical makers, and how they manifested between exposed and less-exposed occupations, were explored in addition to how duration of exposure altered these clinical markers. In regression analysis, Diastolic Blood Pressure (DBP) and high-density lipoprotein (HDL) cholesterol, were significantly associated with blood lead level (BLL). In the occupational analysis, Systolic Blood Pressure (SBP), DBP, C-reactive protein (CRP), triglycerides, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, showed differences between populations in the exposed and less-exposed occupations. Regarding Agriculture, Forestry & Fishing, the duration of exposure altered SBP, CRP, and LDL cholesterol. With mining, the duration of exposure altered SBP, DBP, triglycerides, and HDL cholesterol, whereas in construction, the duration in occupation altered SBP, triglycerides, and CRP. In conclusion, lead exposure has a profound effect on the cardiovascular system, with potentially adverse outcomes existing at all exposure levels.

Original languageEnglish
Article number759
JournalInternational Journal of Environmental Research and Public Health
Issue number4
StatePublished - 15 Apr 2018
Externally publishedYes


  • Blood pressure
  • Cardiovascular
  • Clinical markers
  • Lead exposure
  • Lipid profile
  • Occupational


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