Case Report of an Urgent Determination of Malignant Hyperthermia Status of a 24-Week Pregnant Patient Requiring Intrauterine Fetal Surgery

Maria D Tischer; David J Berman; Luke Michaelson; Erin A Tracy; Rachel E Bridwell; Angela M Curell

doi:10.1213/XAA.0000000000001868

Case Report of an Urgent Determination of Malignant Hyperthermia Status of a 24-Week Pregnant Patient Requiring Intrauterine Fetal Surgery

Maria D Tischer, David J Berman, Luke Michaelson, Erin A Tracy, Rachel E Bridwell, Angela M Curell

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Malignant hyperthermia (MH) is a potentially fatal disorder triggered by volatile anesthetics or succinylcholine, inducing a hypermetabolic crisis in susceptible patients. The caffeine-halothane contracture test (CHCT) remains a gold standard for MH detection. The authors describe a pregnant patient with a history of exertional rhabdomyolysis, who required urgent MH screening for administration of MH-triggering anesthetics. This anesthetic plan allowed for an in utero myelomeningocele repair for a 24-week-old fetus. A multi-institutional team coordinated the urgent CHCT and repair with a favorable outcome.

Original language	English
Pages (from-to)	e01868
Journal	A&A practice
Volume	18
Issue number	12
DOIs	https://doi.org/10.1213/XAA.0000000000001868
State	Published - 1 Dec 2024
Externally published	Yes

Keywords

Humans
Female
Pregnancy
Malignant Hyperthermia/diagnosis
Adult
Caffeine/administration & dosage
Halothane
Rhabdomyolysis
Meningomyelocele/surgery
Anesthetics, Inhalation/administration & dosage

Access to Document

10.1213/XAA.0000000000001868

Cite this

@article{adc8c957c15143ad89e6e1ffc7ac3a93,

title = "Case Report of an Urgent Determination of Malignant Hyperthermia Status of a 24-Week Pregnant Patient Requiring Intrauterine Fetal Surgery",

abstract = "Malignant hyperthermia (MH) is a potentially fatal disorder triggered by volatile anesthetics or succinylcholine, inducing a hypermetabolic crisis in susceptible patients. The caffeine-halothane contracture test (CHCT) remains a gold standard for MH detection. The authors describe a pregnant patient with a history of exertional rhabdomyolysis, who required urgent MH screening for administration of MH-triggering anesthetics. This anesthetic plan allowed for an in utero myelomeningocele repair for a 24-week-old fetus. A multi-institutional team coordinated the urgent CHCT and repair with a favorable outcome.",

keywords = "Humans, Female, Pregnancy, Malignant Hyperthermia/diagnosis, Adult, Caffeine/administration & dosage, Halothane, Rhabdomyolysis, Meningomyelocele/surgery, Anesthetics, Inhalation/administration & dosage",

author = "Tischer, {Maria D} and Berman, {David J} and Luke Michaelson and Tracy, {Erin A} and Bridwell, {Rachel E} and Curell, {Angela M}",

note = "Copyright {\textcopyright} 2024 International Anesthesia Research Society.",

year = "2024",

month = dec,

day = "1",

doi = "10.1213/XAA.0000000000001868",

language = "English",

volume = "18",

pages = "e01868",

journal = "A&A practice",

issn = "2575-3126",

publisher = "Wolters Kluwer Health",

number = "12",

}

TY - JOUR

T1 - Case Report of an Urgent Determination of Malignant Hyperthermia Status of a 24-Week Pregnant Patient Requiring Intrauterine Fetal Surgery

AU - Tischer, Maria D

AU - Berman, David J

AU - Michaelson, Luke

AU - Tracy, Erin A

AU - Bridwell, Rachel E

AU - Curell, Angela M

PY - 2024/12/1

Y1 - 2024/12/1

N2 - Malignant hyperthermia (MH) is a potentially fatal disorder triggered by volatile anesthetics or succinylcholine, inducing a hypermetabolic crisis in susceptible patients. The caffeine-halothane contracture test (CHCT) remains a gold standard for MH detection. The authors describe a pregnant patient with a history of exertional rhabdomyolysis, who required urgent MH screening for administration of MH-triggering anesthetics. This anesthetic plan allowed for an in utero myelomeningocele repair for a 24-week-old fetus. A multi-institutional team coordinated the urgent CHCT and repair with a favorable outcome.

AB - Malignant hyperthermia (MH) is a potentially fatal disorder triggered by volatile anesthetics or succinylcholine, inducing a hypermetabolic crisis in susceptible patients. The caffeine-halothane contracture test (CHCT) remains a gold standard for MH detection. The authors describe a pregnant patient with a history of exertional rhabdomyolysis, who required urgent MH screening for administration of MH-triggering anesthetics. This anesthetic plan allowed for an in utero myelomeningocele repair for a 24-week-old fetus. A multi-institutional team coordinated the urgent CHCT and repair with a favorable outcome.

KW - Humans

KW - Female

KW - Pregnancy

KW - Malignant Hyperthermia/diagnosis

KW - Adult

KW - Caffeine/administration & dosage

KW - Halothane

KW - Rhabdomyolysis

KW - Meningomyelocele/surgery

KW - Anesthetics, Inhalation/administration & dosage

U2 - 10.1213/XAA.0000000000001868

DO - 10.1213/XAA.0000000000001868

M3 - Article

C2 - 39636035

SN - 2575-3126

VL - 18

SP - e01868

JO - A&A practice

JF - A&A practice

IS - 12

ER -