CD38 expression on cryopreserved CD8+ T cells predicts HIV disease progression

Stephen P. Perfetto*, John D. Malone, Clifton Hawkes, Gilbert McCrary, Bob August, Susan Zhou, Robin Garner, Matthew J. Dolan, Arthur E. Brown

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Previous studies have revealed that the expression of CD38 on CD8+ T cells is a strong predictor of disease progression in human immunodeficiency virus (HIV)-infected individuals. Those studies were performed using fresh patient samples over an extended trim period. After demonstrating the validity of assay results on cryopreserved cells, we performed a retrospective study using frozen cell samples to determine the predictive value of CD38 expression in patients with CD4 counts above 400 cells/μl. The CD38 expression as measured by antibody binding capacity and the CD38 median channel were shown to be associated with time to new opportunistic infection or death (both P < 0.001). These results suggest that CD38 expression on CD8+ T cells, whether fresh or frozen, provides a useful predictor of HIV disease progression.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
Issue number2
StatePublished - 1 Oct 1998
Externally publishedYes


  • Acquired immunodeficiency syndrome
  • CD38 antigen
  • Human immunodeficiency virus
  • Immunophenotyping
  • Prognosis
  • Relative fluorescence intensity


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