CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection

Denise C. Hsu*, Matthew D. Wegner, Piyanate Sunyakumthorn, Decha Silsorn, Sujitra Tayamun, Dutsadee Inthawong, Yanin Kuncharin, Rawiwan Im-Erbsin, Christine Ege, Robert J. O'Connell, Nelson L. Michael, Lishomwa C. Ndhlovu, Sandhya Vasan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Limited longitudinal data exist on the effect of HIV on adipose tissue (AT). We found an increase in CD4+ cells and detectable SHIV-RNA in AT during acute SHIV infection. SHIV-RNA+ cells were rare, suggesting that AT is unlikely to be a major source of productively infected cells in SHIV infection.

Original languageEnglish
Pages (from-to)154-157
Number of pages4
JournalJournal of Medical Primatology
Volume46
Issue number4
DOIs
StatePublished - Aug 2017
Externally publishedYes

Keywords

  • CD4
  • HIV
  • RNA
  • fat
  • inflammation

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