CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection

Denise C. Hsu; Matthew D. Wegner; Piyanate Sunyakumthorn; Decha Silsorn; Sujitra Tayamun; Dutsadee Inthawong; Yanin Kuncharin; Rawiwan Im-Erbsin; Christine Ege; Robert J. O'Connell; Nelson L. Michael; Lishomwa C. Ndhlovu; Sandhya Vasan

doi:10.1111/jmp.12298

CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection

Denise C. Hsu^*, Matthew D. Wegner, Piyanate Sunyakumthorn, Decha Silsorn, Sujitra Tayamun, Dutsadee Inthawong, Yanin Kuncharin, Rawiwan Im-Erbsin, Christine Ege, Robert J. O'Connell, Nelson L. Michael, Lishomwa C. Ndhlovu, Sandhya Vasan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Limited longitudinal data exist on the effect of HIV on adipose tissue (AT). We found an increase in CD4+ cells and detectable SHIV-RNA in AT during acute SHIV infection. SHIV-RNA+ cells were rare, suggesting that AT is unlikely to be a major source of productively infected cells in SHIV infection.

Original language	English
Pages (from-to)	154-157
Number of pages	4
Journal	Journal of Medical Primatology
Volume	46
Issue number	4
DOIs	https://doi.org/10.1111/jmp.12298
State	Published - Aug 2017
Externally published	Yes

Keywords

CD4
HIV
RNA
fat
inflammation

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10.1111/jmp.12298

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Hsu, D. C., Wegner, M. D., Sunyakumthorn, P., Silsorn, D., Tayamun, S., Inthawong, D., Kuncharin, Y., Im-Erbsin, R., Ege, C., O'Connell, R. J., Michael, N. L., Ndhlovu, L. C., & Vasan, S. (2017). CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection. Journal of Medical Primatology, 46(4), 154-157. https://doi.org/10.1111/jmp.12298

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title = "CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection",

abstract = "Limited longitudinal data exist on the effect of HIV on adipose tissue (AT). We found an increase in CD4+ cells and detectable SHIV-RNA in AT during acute SHIV infection. SHIV-RNA+ cells were rare, suggesting that AT is unlikely to be a major source of productively infected cells in SHIV infection.",

keywords = "CD4, HIV, RNA, fat, inflammation",

author = "Hsu, {Denise C.} and Wegner, {Matthew D.} and Piyanate Sunyakumthorn and Decha Silsorn and Sujitra Tayamun and Dutsadee Inthawong and Yanin Kuncharin and Rawiwan Im-Erbsin and Christine Ege and O'Connell, {Robert J.} and Michael, {Nelson L.} and Ndhlovu, {Lishomwa C.} and Sandhya Vasan",

note = "Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

year = "2017",

month = aug,

doi = "10.1111/jmp.12298",

language = "English",

volume = "46",

pages = "154--157",

journal = "Journal of Medical Primatology",

issn = "0047-2565",

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Hsu, DC, Wegner, MD, Sunyakumthorn, P, Silsorn, D, Tayamun, S, Inthawong, D, Kuncharin, Y, Im-Erbsin, R, Ege, C, O'Connell, RJ , Michael, NL, Ndhlovu, LC & Vasan, S 2017, 'CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection', Journal of Medical Primatology, vol. 46, no. 4, pp. 154-157. https://doi.org/10.1111/jmp.12298

TY - JOUR

T1 - CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection

AU - Hsu, Denise C.

AU - Wegner, Matthew D.

AU - Sunyakumthorn, Piyanate

AU - Silsorn, Decha

AU - Tayamun, Sujitra

AU - Inthawong, Dutsadee

AU - Kuncharin, Yanin

AU - Im-Erbsin, Rawiwan

AU - Ege, Christine

AU - O'Connell, Robert J.

AU - Michael, Nelson L.

AU - Ndhlovu, Lishomwa C.

AU - Vasan, Sandhya

PY - 2017/8

Y1 - 2017/8

N2 - Limited longitudinal data exist on the effect of HIV on adipose tissue (AT). We found an increase in CD4+ cells and detectable SHIV-RNA in AT during acute SHIV infection. SHIV-RNA+ cells were rare, suggesting that AT is unlikely to be a major source of productively infected cells in SHIV infection.

AB - Limited longitudinal data exist on the effect of HIV on adipose tissue (AT). We found an increase in CD4+ cells and detectable SHIV-RNA in AT during acute SHIV infection. SHIV-RNA+ cells were rare, suggesting that AT is unlikely to be a major source of productively infected cells in SHIV infection.

KW - CD4

KW - HIV

KW - RNA

KW - fat

KW - inflammation

UR - http://www.scopus.com/inward/record.url?scp=85025828396&partnerID=8YFLogxK

U2 - 10.1111/jmp.12298

DO - 10.1111/jmp.12298

M3 - Article

C2 - 28748665

AN - SCOPUS:85025828396

SN - 0047-2565

VL - 46

SP - 154

EP - 157

JO - Journal of Medical Primatology

JF - Journal of Medical Primatology

IS - 4

ER -

CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection

Abstract

Keywords

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