Cellular events in tolerance. III. Carrier tolerance as a model for T cell unresponsiveness

F. Sanfilippo, D. W. Scott

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Lewis rats pretreated with 10 mg of the soluble supernatant of ultracentrifuged sheep γ globulins (ShIgSo) and challenged with trinitrophenylated (TNP) ShIg in adjuvant initially developed significantly fewer anti TNP plaque forming cells than untreated controls. The effect was specific because ShIgSo tolerant rats responded normally to TNP rabbit γ globulin. Carrier tolerance lasted at least 6 months and could be induced with as little as 100 μg ShIgSo. Adoptive transfer experiments to irradiated recipients demonstrated that thymocytes could reverse carrier unresponsiveness. 'Suppressor' cells were not detectable in carrier tolerant spleen populations. The diminution of responsiveness to TNP on a tolerated carrier thus provides a model for the study of T cell unresponsiveness in vivo.

Original languageEnglish
Pages (from-to)1661-1667
Number of pages7
JournalJournal of Immunology
Issue number6
StatePublished - 1974
Externally publishedYes


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