Cellular identity crisis: Antiandrogen resistance by lineage plasticity

Daniel Tuerff, Tristan Sissung, William D. Figg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A recent publication in Science demonstrates the ability of prostate cancer cells to switch lineages from one that is dependent on androgen signaling to a cell type that is not. Known as lineage plasticity, this phenomenon is driven by the transcription factor SOX2 in RB1 and TP53-deficient prostate cancer. SOX2 is a potential prognostic marker and therapeutic target in castration resistant prostate cancer.

Original languageEnglish
Pages (from-to)841-842
Number of pages2
JournalCancer Biology and Therapy
Issue number11
StatePublished - 2 Nov 2017
Externally publishedYes


  • CRPC
  • Lineage plasticity
  • RB1
  • SOX2
  • TP53
  • antiandrogen
  • prostate cancer


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