Cellular identity crisis: Antiandrogen resistance by lineage plasticity

Daniel Tuerff; Tristan Sissung; William D. Figg

doi:10.1080/15384047.2017.1323599

Cellular identity crisis: Antiandrogen resistance by lineage plasticity

Daniel Tuerff
, Tristan Sissung
, William D. Figg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A recent publication in Science demonstrates the ability of prostate cancer cells to switch lineages from one that is dependent on androgen signaling to a cell type that is not. Known as lineage plasticity, this phenomenon is driven by the transcription factor SOX2 in RB1 and TP53-deficient prostate cancer. SOX2 is a potential prognostic marker and therapeutic target in castration resistant prostate cancer.

Original language	English
Pages (from-to)	841-842
Number of pages	2
Journal	Cancer Biology and Therapy
Volume	18
Issue number	11
DOIs	https://doi.org/10.1080/15384047.2017.1323599
State	Published - 2 Nov 2017
Externally published	Yes

Keywords

CRPC
Lineage plasticity
RB1
SOX2
TP53
antiandrogen
prostate cancer

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10.1080/15384047.2017.1323599

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title = "Cellular identity crisis: Antiandrogen resistance by lineage plasticity",

abstract = "A recent publication in Science demonstrates the ability of prostate cancer cells to switch lineages from one that is dependent on androgen signaling to a cell type that is not. Known as lineage plasticity, this phenomenon is driven by the transcription factor SOX2 in RB1 and TP53-deficient prostate cancer. SOX2 is a potential prognostic marker and therapeutic target in castration resistant prostate cancer.",

keywords = "CRPC, Lineage plasticity, RB1, SOX2, TP53, antiandrogen, prostate cancer",

author = "Daniel Tuerff and Tristan Sissung and Figg, \{William D.\}",

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AU - Figg, William D.

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AB - A recent publication in Science demonstrates the ability of prostate cancer cells to switch lineages from one that is dependent on androgen signaling to a cell type that is not. Known as lineage plasticity, this phenomenon is driven by the transcription factor SOX2 in RB1 and TP53-deficient prostate cancer. SOX2 is a potential prognostic marker and therapeutic target in castration resistant prostate cancer.

KW - CRPC

KW - Lineage plasticity

KW - RB1

KW - SOX2

KW - TP53

KW - antiandrogen

KW - prostate cancer

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JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

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ER -

Cellular identity crisis: Antiandrogen resistance by lineage plasticity

Abstract

Keywords

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