Central and peripheral effects of arecoline in patients with autonomic failure

Ronald J. Polinsky; Robert T. Brown; M. Teresa Curras; Susan M. Baser; Celeste E. Baucom; Douglas R. Hooper; Ann M. Marini

doi:10.1136/jnnp.54.9.807

Central and peripheral effects of arecoline in patients with autonomic failure

Ronald J. Polinsky^*, Robert T. Brown, M. Teresa Curras, Susan M. Baser, Celeste E. Baucom, Douglas R. Hooper, Ann M. Marini

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Increased plasma adrenalin (A) levels following arecoline in normal subjects and patients with multiple system atrophy (MSA) may result from nicotinic adrenal stimulation. Lack of this response in patients with pure autonomic failure (PAF) is consistent with peripheral sympathetic dysfunction. The mechanisms underlying diminished plasma corticotropin (ACTH) responses to arecoline may differ in patients with autonomic failure. Hypothalamic, cholinergic degeneration could prevent the response in MSA whereas patients with PAF do not manifest the normal increase in A which may be required to elicit an ACTH response. The appearance and exacerbation of tremor, vertigo, and pathological affect in the MSA group suggest that some central cholinergic receptors remain functional.

Original language	English
Pages (from-to)	807-812
Number of pages	6
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	54
Issue number	9
DOIs	https://doi.org/10.1136/jnnp.54.9.807
State	Published - 1991
Externally published	Yes

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10.1136/jnnp.54.9.807

Cite this

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title = "Central and peripheral effects of arecoline in patients with autonomic failure",

abstract = "Increased plasma adrenalin (A) levels following arecoline in normal subjects and patients with multiple system atrophy (MSA) may result from nicotinic adrenal stimulation. Lack of this response in patients with pure autonomic failure (PAF) is consistent with peripheral sympathetic dysfunction. The mechanisms underlying diminished plasma corticotropin (ACTH) responses to arecoline may differ in patients with autonomic failure. Hypothalamic, cholinergic degeneration could prevent the response in MSA whereas patients with PAF do not manifest the normal increase in A which may be required to elicit an ACTH response. The appearance and exacerbation of tremor, vertigo, and pathological affect in the MSA group suggest that some central cholinergic receptors remain functional.",

author = "Polinsky, {Ronald J.} and Brown, {Robert T.} and Curras, {M. Teresa} and Baser, {Susan M.} and Baucom, {Celeste E.} and Hooper, {Douglas R.} and Marini, {Ann M.}",

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AU - Polinsky, Ronald J.

AU - Brown, Robert T.

AU - Curras, M. Teresa

AU - Baser, Susan M.

AU - Baucom, Celeste E.

AU - Hooper, Douglas R.

AU - Marini, Ann M.

PY - 1991

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AB - Increased plasma adrenalin (A) levels following arecoline in normal subjects and patients with multiple system atrophy (MSA) may result from nicotinic adrenal stimulation. Lack of this response in patients with pure autonomic failure (PAF) is consistent with peripheral sympathetic dysfunction. The mechanisms underlying diminished plasma corticotropin (ACTH) responses to arecoline may differ in patients with autonomic failure. Hypothalamic, cholinergic degeneration could prevent the response in MSA whereas patients with PAF do not manifest the normal increase in A which may be required to elicit an ACTH response. The appearance and exacerbation of tremor, vertigo, and pathological affect in the MSA group suggest that some central cholinergic receptors remain functional.

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