Changes in viscoelastic properties of brain tissue due to traumatic injury

Kurosh Darvish*, James Stone

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


In this study, changes in viscoelastic material properties of brain tissue due to traumatic axonal injury (TAI) were investigated. The impact acceleration model was used to generate diffuse axonal injury in rat brain. TAI in the corticospinal (CSpT) tract in the brain stem was quantified using amyloid precursor protein immunostaining. Material properties along the CSpT were determined using an indentation technique. The results showed that the number of injured axons at the pyramidal decussation (PDx) was approximated 10 times higher than in the ponto-medullary junction (PmJ). The instantaneous elastic response was reduced approximately 70% at PDx compared to 40% at PmJ and the relaxation was uniformly reduced approximately 30%, which were attributed to the effect of injury on tissue properties. Application of a visco-elastic-plastic model that changes due to TAI can significantly alter the results of computational models of brain injury.

Original languageEnglish
Article numberIMECE2004-60849
Pages (from-to)291-292
Number of pages2
JournalAdvances in Bioengineering, BED
StatePublished - 2004
Externally publishedYes
Event2004 ASME International Mechanical Engineering Congress and Exposition, IMECE - Anaheim, CA, United States
Duration: 13 Nov 200419 Nov 2004


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