Characterizing Restricted Diffusion in Pre-/Post- treatment Gliomas Using Time-dependent Diffusion MRI at Ultra-high-gradient Human 3.0T

Ante Zhu; Robert Shih; James DeMarco; Herman Morris; Radhika Madhavan; Gail Kohls; Tim Sprenger; Maureen Hood; Luca Marinelli; Jason Gregory; Brett Theeler; Vincent Ho; Thomas Foo

doi:10.58530/2022/3410

Characterizing Restricted Diffusion in Pre-/Post- treatment Gliomas Using Time-dependent Diffusion MRI at Ultra-high-gradient Human 3.0T

Ante Zhu, Robert Shih, James DeMarco, Herman Morris, Radhika Madhavan, Gail Kohls, Tim Sprenger, Maureen Hood, Luca Marinelli, Jason Gregory, Brett Theeler, Vincent Ho, Thomas Foo

Research output: Contribution to conference › Paper › peer-review

Abstract

Time-dependent diffusion MRI has shown high specificity to non-Gaussian restricted diffusion, which improves assessing cytoarchitectural alternations in pre-/post- treatment glioma. However, the characterization of time-dependent diffusivity ADC( f ) and kurtosis MK( f ) at short diffusion time using oscillating gradient spin echo (OGSE) diffusion encoding is limited. In our preliminary studies at ultra-high-gradient 3.0T, larger changes of ADC( f ) and MK( f ) were shown in glioblastoma compared to a low-grade astrocytoma, indicating highly restricted microenvironment as confirmed on histopathology. OGSE-based time-dependent diffusion showed promise for evaluating cytoarchitectural alternations in gliomas. ADC( f ) and MK( f ) of contrast-enhancing lesions in three post-glioblastoma-treatment patients showed strong time-dependence.

Original language	American English
DOIs	https://doi.org/10.58530/2022/3410
State	Published - 2022

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10.58530/2022/3410

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title = "Characterizing Restricted Diffusion in Pre-/Post- treatment Gliomas Using Time-dependent Diffusion MRI at Ultra-high-gradient Human 3.0T",

abstract = " Time-dependent diffusion MRI has shown high specificity to non-Gaussian restricted diffusion, which improves assessing cytoarchitectural alternations in pre-/post- treatment glioma. However, the characterization of time-dependent diffusivity ADC( f ) and kurtosis MK( f ) at short diffusion time using oscillating gradient spin echo (OGSE) diffusion encoding is limited. In our preliminary studies at ultra-high-gradient 3.0T, larger changes of ADC( f ) and MK( f ) were shown in glioblastoma compared to a low-grade astrocytoma, indicating highly restricted microenvironment as confirmed on histopathology. OGSE-based time-dependent diffusion showed promise for evaluating cytoarchitectural alternations in gliomas. ADC( f ) and MK( f ) of contrast-enhancing lesions in three post-glioblastoma-treatment patients showed strong time-dependence. ",

author = "Ante Zhu and Robert Shih and James DeMarco and Herman Morris and Radhika Madhavan and Gail Kohls and Tim Sprenger and Maureen Hood and Luca Marinelli and Jason Gregory and Brett Theeler and Vincent Ho and Thomas Foo",

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TY - CONF

T1 - Characterizing Restricted Diffusion in Pre-/Post- treatment Gliomas Using Time-dependent Diffusion MRI at Ultra-high-gradient Human 3.0T

AU - Zhu, Ante

AU - Shih, Robert

AU - DeMarco, James

AU - Morris, Herman

AU - Madhavan, Radhika

AU - Kohls, Gail

AU - Sprenger, Tim

AU - Hood, Maureen

AU - Marinelli, Luca

AU - Gregory, Jason

AU - Theeler, Brett

AU - Ho, Vincent

AU - Foo, Thomas

PY - 2022

Y1 - 2022

N2 - Time-dependent diffusion MRI has shown high specificity to non-Gaussian restricted diffusion, which improves assessing cytoarchitectural alternations in pre-/post- treatment glioma. However, the characterization of time-dependent diffusivity ADC( f ) and kurtosis MK( f ) at short diffusion time using oscillating gradient spin echo (OGSE) diffusion encoding is limited. In our preliminary studies at ultra-high-gradient 3.0T, larger changes of ADC( f ) and MK( f ) were shown in glioblastoma compared to a low-grade astrocytoma, indicating highly restricted microenvironment as confirmed on histopathology. OGSE-based time-dependent diffusion showed promise for evaluating cytoarchitectural alternations in gliomas. ADC( f ) and MK( f ) of contrast-enhancing lesions in three post-glioblastoma-treatment patients showed strong time-dependence.

AB - Time-dependent diffusion MRI has shown high specificity to non-Gaussian restricted diffusion, which improves assessing cytoarchitectural alternations in pre-/post- treatment glioma. However, the characterization of time-dependent diffusivity ADC( f ) and kurtosis MK( f ) at short diffusion time using oscillating gradient spin echo (OGSE) diffusion encoding is limited. In our preliminary studies at ultra-high-gradient 3.0T, larger changes of ADC( f ) and MK( f ) were shown in glioblastoma compared to a low-grade astrocytoma, indicating highly restricted microenvironment as confirmed on histopathology. OGSE-based time-dependent diffusion showed promise for evaluating cytoarchitectural alternations in gliomas. ADC( f ) and MK( f ) of contrast-enhancing lesions in three post-glioblastoma-treatment patients showed strong time-dependence.

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