Chemoprophylaxis against group A streptococcus during military training

Bryant J. Webber*, John W. Kieffer, Brian K. White, Anthony W. Hawksworth, Paul C.F. Graf, Heather C. Yun

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Chemoprophylaxis with intramuscular benzathine penicillin G has been used widely by the U.S. military to prevent epidemics of group A streptococcus infections during basic training. The recent global shortage of benzathine penicillin prompted a detailed analysis of this issue in 2017 by military preventive medicine and infectious disease authorities in San Antonio, Texas, and San Diego, California, USA. This paper explores the history of group A streptococcus and chemoprophylaxis in the U.S. military training environment, current policy and practice, and challenges associated with widespread chemoprophylaxis. In light of the history presented, preventive medicine authorities at basic training centers should be extremely cautious about discontinuing benzathine penicillin chemoprophylaxis.

Original languageEnglish
Pages (from-to)142-149
Number of pages8
JournalPreventive Medicine
StatePublished - Jan 2019
Externally publishedYes


  • Chemoprevention
  • Military personnel
  • Penicillin G benzathine
  • Streptococcus


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