Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of Guam

Eliezer Masliah; Michael Alford; Douglas Galasko; David Salmon; Lawrence A. Hansen; Paul F. Good; Daniel P. Perl; Leon Thal

doi:10.1097/00001756-200112210-00009

Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of Guam

Eliezer Masliah^*
, Michael Alford
, Douglas Galasko
, David Salmon
, Lawrence A. Hansen
, Paul F. Good
, Daniel P. Perl
, Leon Thal

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Patients with parkinsonism-dementia complex (PDC) of Guam showed moderate loss of choline acetyl transferase activity in the midfrontal and inferior parietal cortex, and severe loss in the superior temporal cortex. This deficit was similar to that seen in Alzheimer's disease and less severe than Lewy body disease. Thus, cholinergic deficits in the neocortex might contribute to some of the cognitive alterations in PDC of Guam.

Original language	English
Pages (from-to)	3901-3903
Number of pages	3
Journal	NeuroReport
Volume	12
Issue number	18
DOIs	https://doi.org/10.1097/00001756-200112210-00009
State	Published - 21 Dec 2001

Keywords

Alzheimer's disease
Cholinergic presynaptic terminals
Lewy body disease
Parkinson's disease
Parkinsonism-dementia complex

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10.1097/00001756-200112210-00009

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title = "Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of Guam",

abstract = "Patients with parkinsonism-dementia complex (PDC) of Guam showed moderate loss of choline acetyl transferase activity in the midfrontal and inferior parietal cortex, and severe loss in the superior temporal cortex. This deficit was similar to that seen in Alzheimer's disease and less severe than Lewy body disease. Thus, cholinergic deficits in the neocortex might contribute to some of the cognitive alterations in PDC of Guam.",

keywords = "Alzheimer's disease, Cholinergic presynaptic terminals, Lewy body disease, Parkinson's disease, Parkinsonism-dementia complex",

author = "Eliezer Masliah and Michael Alford and Douglas Galasko and David Salmon and Hansen, \{Lawrence A.\} and Good, \{Paul F.\} and Perl, \{Daniel P.\} and Leon Thal",

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T1 - Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of Guam

AU - Masliah, Eliezer

AU - Alford, Michael

AU - Galasko, Douglas

AU - Salmon, David

AU - Hansen, Lawrence A.

AU - Good, Paul F.

AU - Perl, Daniel P.

AU - Thal, Leon

PY - 2001/12/21

Y1 - 2001/12/21

N2 - Patients with parkinsonism-dementia complex (PDC) of Guam showed moderate loss of choline acetyl transferase activity in the midfrontal and inferior parietal cortex, and severe loss in the superior temporal cortex. This deficit was similar to that seen in Alzheimer's disease and less severe than Lewy body disease. Thus, cholinergic deficits in the neocortex might contribute to some of the cognitive alterations in PDC of Guam.

AB - Patients with parkinsonism-dementia complex (PDC) of Guam showed moderate loss of choline acetyl transferase activity in the midfrontal and inferior parietal cortex, and severe loss in the superior temporal cortex. This deficit was similar to that seen in Alzheimer's disease and less severe than Lewy body disease. Thus, cholinergic deficits in the neocortex might contribute to some of the cognitive alterations in PDC of Guam.

KW - Alzheimer's disease

KW - Cholinergic presynaptic terminals

KW - Lewy body disease

KW - Parkinson's disease

KW - Parkinsonism-dementia complex

UR - https://www.scopus.com/pages/publications/0035930482

U2 - 10.1097/00001756-200112210-00009

DO - 10.1097/00001756-200112210-00009

M3 - Article

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AN - SCOPUS:0035930482

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VL - 12

SP - 3901

EP - 3903

JO - NeuroReport

JF - NeuroReport

IS - 18

ER -

Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of Guam

Abstract

Keywords

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