TY - JOUR
T1 - Circulating and unique recombinant forms of HIV type 1 containing subsubtype A2
AU - Visawapoka, Unchalee
AU - Tovanabutra, Sodsai
AU - Currier, Jeffrey R.
AU - Cox, Josephine H.
AU - Mason, Carl J.
AU - Wasunna, Monique
AU - Ponglikitmongkol, Mathurose
AU - Dowling, William E.
AU - Robb, Merlin L.
AU - Birx, Deborah L.
AU - McCutchan, Francine E.
PY - 2006/7/1
Y1 - 2006/7/1
N2 - HIV-1 strains containing sabsubtype A2 are relatively rare in the pandemic but have been repeatedly identified in Kenya, where candidate vaccines based in part on subtype A, but not A2 strains, may be evaluated. Among the most recent is CRF16_A2D, a circulating recombinant form (CMF) whose prototypes are complete or partial IUV-I sequences from Kenya, Korea, and Argentina. Using samples from blood bank discards in Kenya and complete genome sequencing, this report further documents CRF16_A2D and related recombinants and identifies a second CRF, CRF21_A2D. The two A2-containing CRFs, and two recombinants related to CRF16_A2D, share common structural elements bat appear to have been independently derived. Concerted selection may have influenced the emergence and spread of certain A2-containing strains in Kenya. The second complete subtype C sequence from Kenya is also reported here. Monitoring of A2-containing recombinants and subtype C strains, both relatively rare in Kenya, may be informative in the course of cohort development and evaluation of candidate vaccines.
AB - HIV-1 strains containing sabsubtype A2 are relatively rare in the pandemic but have been repeatedly identified in Kenya, where candidate vaccines based in part on subtype A, but not A2 strains, may be evaluated. Among the most recent is CRF16_A2D, a circulating recombinant form (CMF) whose prototypes are complete or partial IUV-I sequences from Kenya, Korea, and Argentina. Using samples from blood bank discards in Kenya and complete genome sequencing, this report further documents CRF16_A2D and related recombinants and identifies a second CRF, CRF21_A2D. The two A2-containing CRFs, and two recombinants related to CRF16_A2D, share common structural elements bat appear to have been independently derived. Concerted selection may have influenced the emergence and spread of certain A2-containing strains in Kenya. The second complete subtype C sequence from Kenya is also reported here. Monitoring of A2-containing recombinants and subtype C strains, both relatively rare in Kenya, may be informative in the course of cohort development and evaluation of candidate vaccines.
UR - http://www.scopus.com/inward/record.url?scp=33745951215&partnerID=8YFLogxK
U2 - 10.1089/aid.2006.22.695
DO - 10.1089/aid.2006.22.695
M3 - Article
C2 - 16831094
AN - SCOPUS:33745951215
SN - 0889-2229
VL - 22
SP - 695
EP - 702
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 7
ER -