Class I HLA-A*7401 is associated with protection from HIV-1 acquisition and disease progression in Mbeya, Tanzania

Rebecca N. Koehler, Anne M. Walsh, Elmar Saathoff, Sodsai Tovanabutra, Miguel A. Arroyo, Jeffery R. Currier, Leonard Maboko, Michael Hoelsher, Merlin L. Robb, Nelson L. Michael, Francine E. McCutchan, Jerome H. Kim, Gustavo H. Kijak

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32 Scopus citations

Abstract

Here we explore associations between HLA variation and human immunodeficiency virus type 1 (HIV-1) acquisition and disease progression in a community cohort in Mbeya, Tanzania, a region that, despite harboring high rates of HIV-1 infection, remains understudied. African-specific allele HLA-A*74:01 was associated with decreased risk of infection (odds ratio [OR], 0.37; 95% confidence interval [CI], 0.14-0.80; P = .011) and with protection from CD4+ cell counts <200 cells/uL in women (OR, 0.31; 95% CI, 0.07-0.91; P = .032) and men (OR, 0.15; 95% CI, 0.01-0.78; P = .020). These associations remained significant after adjustment for linkage disequilibrium with HLA-B and HLA-C alleles. This observation calls for additional investigation of mechanisms by which HLA-A*74:01 may influence HIV-1 acquisition and control of the infection.

Original languageEnglish
Pages (from-to)1562-1566
Number of pages5
JournalJournal of Infectious Diseases
Volume202
Issue number10
DOIs
StatePublished - 15 Nov 2010
Externally publishedYes

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