Clinical applications of proteomics

Emanuel F. Petricoin*, Lance A. Liotta

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

Proteomics, the systematic evaluation of changes in the protein constituency of a cell, is more than just the generation of lists of proteins that increase or decrease in expression as a cause or consequence of disease. The ultimate goal is to characterize the information flow through protein pathways that interconnect the extracellular microenvironment with the control of gene transcription. The nature of this information can be a cause or a consequence of disease processes. Clinical applications of proteomics involve the use of proteomic technologies at the bedside. The analysis of human cancer as a model for how proteomics can have an impact at the bedside is now employing several new proteomic technologies that are being developed for early detection, therapeutic targeting and finally, patient-tailored therapy.

Original languageEnglish
Pages (from-to)2476S-2484S
JournalJournal of Nutrition
Volume133
Issue number7 SUPPL.
DOIs
StatePublished - 1 Jul 2003
Externally publishedYes

Keywords

  • Cell signaling
  • Pattern diagnostics
  • Protein microarrays
  • Proteomics
  • SELDI

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