Clinical applications of proteomics: Proteomic pattern diagnostics

Emanuel F. Petricoin*, Cloud P. Paweletz, Lance A. Liotta

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations


Clinical proteomics is an exciting new subdiscipline of proteomics that involves bedside application of proteomic technologies. A new and potentially revolutionary technology and approach for early disease detection, surveillance, and monitoring is proteomic pattern diagnostics. Using this approach, high throughput mass spectrometry generates a proteomic fingerprint of a given body fluid, such as serum or nipple fluid aspirants (NAF), in less than 30 s. This information archive is then used by new types of bioinformatic pattern recognition algorithms to identify patterns of protein changes that can discriminate cancer from healthy and unaffected individuals. This entire process can take place in less than a minute and requires only a droplet of blood, NAF, or ductal lavage washings. The new concept that is introduced by this platform is that the underlying identities of the proteins that comprise the patterns are not known and do not need to be known; the pattern itself becomes the diagnostic.

Original languageEnglish
Pages (from-to)433-440
Number of pages8
JournalJournal of Mammary Gland Biology and Neoplasia
Issue number4
StatePublished - Oct 2002
Externally publishedYes


  • Breast cancer
  • Genetic algorithms
  • Mass spectrometry
  • Nipple fluid
  • Patterns diagnostics
  • Proteomics


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