Clinical experimentation with aerosol antibiotics: Current and future methods of administration

Paul Zarogoulidis*, Ioannis Kioumis, Konstantinos Porpodis, Dionysios Spyratos, Kosmas Tsakiridis, Haidong Huang, Qiang Li, J. Francis Turner, Robert Browning, Wolfgang Hohenforst-Schmidt, Konstantinos Zarogoulidis

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Currently almost all antibiotics are administered by the intravenous route. Since several systems and situations require more efficient methods of administration, investigation and experimentation in drug design has produced local treatment modalities. Administration of antibiotics in aerosol form is one of the treatment methods of increasing interest. As the field of drug nanotechnology grows, new molecules have been produced and combined with aerosol production systems. In the current review, we discuss the efficiency of aerosol antibiotic studies along with aerosol production systems. The different parts of the aerosol antibiotic methodology are presented. Additionally, information regarding the drug molecules used is presented and future applications of this method are discussed.

Original languageEnglish
Pages (from-to)1115-1134
Number of pages20
JournalDrug Design, Development and Therapy
Volume7
DOIs
StatePublished - 1 Oct 2013
Externally publishedYes

Keywords

  • Aerosol
  • Antibiotics
  • Nebulizers

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