Clinical implementation of the Humacyte human acellular vessel: Implications for military and civilian trauma care

Jonathan J. Morrison, John McMahon, Joseph J. DuBose, Thomas M. Scalea, Jeffrey H. Lawson, Todd E. Rasmussen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The incidence of wartime vascular injury has increased and is a leading cause of mortality and morbidity. While ligation remains an option, current resuscitation and damage control techniques have resulted in vascular repair being pursued in more than half of wartime injuries. Options for vascular reconstruction are currently limited to autologous vein or synthetic conduits, choices which have not changed in decades, both of which have problems. Autologous vein is preferable but requires time to harvest and may not be available. Synthetic grafts are poorly resistant to infection and associated with thrombotic complications. Recognizing this capability gap, the US Combat Casualty Care Research Program has partnered with academia and industry to support the development and clinical introduction of a bioengineered human acellular vessel. This human acellular vessel has the potential to be an off-the-shelf conduit that is resistant to infection and incorporates well into native tissues. This report reviews the rationale of this military-civilian partnership in medical innovation and provides an update on the clinical use and ongoing study of this new vascular technology. LEVEL OF EVIDENCE: Therapeutic, level III.

Original languageEnglish
Pages (from-to)S44-S47
JournalJournal of Trauma and Acute Care Surgery
Volume87
Issue number1 S
DOIs
StatePublished - 1 Jul 2019
Externally publishedYes

Keywords

  • Trauma surgery
  • Vascular conduit
  • Vascular trauma

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