Clinical laboratory values as early indicators of ebola virus infection in nonhuman primates

Ronald B. Reisler; Chenggang Yu; Michael J. Donofrio; Travis K. Warren; Jay B. Wells; Kelly S. Stuthman; Nicole L. Garza; Sean A. Vantongeren; Ginger C. Donnelly; Christopher D. Kane; Mark G. Kortepeter; Sina Bavari; Anthony P. Cardile

doi:10.3201/eid2308.170029

Clinical laboratory values as early indicators of ebola virus infection in nonhuman primates

Ronald B. Reisler, Chenggang Yu, Michael J. Donofrio, Travis K. Warren, Jay B. Wells, Kelly S. Stuthman, Nicole L. Garza, Sean A. Vantongeren, Ginger C. Donnelly, Christopher D. Kane, Mark G. Kortepeter, Sina Bavari, Anthony P. Cardile^*

^*Corresponding author for this work

Preventive Medicine and Biostatistics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The Ebola virus (EBOV) outbreak in West Africa during 2013–2016 demonstrated the need to improve Ebola virus disease (EVD) diagnostics and standards of care. This retrospective study compared laboratory values and clinical features of 3 nonhuman primate models of lethal EVD to assess associations with improved survival time. In addition, the study identified laboratory values useful as predictors of survival, surrogates for EBOV viral loads, and triggers for initiation of therapeutic interventions in these nonhuman primate models. Furthermore, the data support that, in nonhuman primates, the Makona strain of EBOV may be less virulent than the Kikwit strain of EBOV. The applicability of these findings as potential diagnostic and management tools for EVD in humans warrants further investigation.

Original language	English
Pages (from-to)	1316-1324
Number of pages	9
Journal	Emerging Infectious Diseases
Volume	23
Issue number	8
DOIs	https://doi.org/10.3201/eid2308.170029
State	Published - Aug 2017

Access to Document

10.3201/eid2308.170029

Cite this

Reisler, R. B., Yu, C., Donofrio, M. J., Warren, T. K., Wells, J. B., Stuthman, K. S., Garza, N. L., Vantongeren, S. A., Donnelly, G. C., Kane, C. D., Kortepeter, M. G., Bavari, S., & Cardile, A. P. (2017). Clinical laboratory values as early indicators of ebola virus infection in nonhuman primates. Emerging Infectious Diseases, 23(8), 1316-1324. https://doi.org/10.3201/eid2308.170029

@article{3b4600d6f75c47b8925c9602d116b76b,

title = "Clinical laboratory values as early indicators of ebola virus infection in nonhuman primates",

abstract = "The Ebola virus (EBOV) outbreak in West Africa during 2013–2016 demonstrated the need to improve Ebola virus disease (EVD) diagnostics and standards of care. This retrospective study compared laboratory values and clinical features of 3 nonhuman primate models of lethal EVD to assess associations with improved survival time. In addition, the study identified laboratory values useful as predictors of survival, surrogates for EBOV viral loads, and triggers for initiation of therapeutic interventions in these nonhuman primate models. Furthermore, the data support that, in nonhuman primates, the Makona strain of EBOV may be less virulent than the Kikwit strain of EBOV. The applicability of these findings as potential diagnostic and management tools for EVD in humans warrants further investigation.",

author = "Reisler, {Ronald B.} and Chenggang Yu and Donofrio, {Michael J.} and Warren, {Travis K.} and Wells, {Jay B.} and Stuthman, {Kelly S.} and Garza, {Nicole L.} and Vantongeren, {Sean A.} and Donnelly, {Ginger C.} and Kane, {Christopher D.} and Kortepeter, {Mark G.} and Sina Bavari and Cardile, {Anthony P.}",

year = "2017",

month = aug,

doi = "10.3201/eid2308.170029",

language = "English",

volume = "23",

pages = "1316--1324",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

number = "8",

}

TY - JOUR

T1 - Clinical laboratory values as early indicators of ebola virus infection in nonhuman primates

AU - Reisler, Ronald B.

AU - Yu, Chenggang

AU - Donofrio, Michael J.

AU - Warren, Travis K.

AU - Wells, Jay B.

AU - Stuthman, Kelly S.

AU - Garza, Nicole L.

AU - Vantongeren, Sean A.

AU - Donnelly, Ginger C.

AU - Kane, Christopher D.

AU - Kortepeter, Mark G.

AU - Bavari, Sina

AU - Cardile, Anthony P.

PY - 2017/8

Y1 - 2017/8

N2 - The Ebola virus (EBOV) outbreak in West Africa during 2013–2016 demonstrated the need to improve Ebola virus disease (EVD) diagnostics and standards of care. This retrospective study compared laboratory values and clinical features of 3 nonhuman primate models of lethal EVD to assess associations with improved survival time. In addition, the study identified laboratory values useful as predictors of survival, surrogates for EBOV viral loads, and triggers for initiation of therapeutic interventions in these nonhuman primate models. Furthermore, the data support that, in nonhuman primates, the Makona strain of EBOV may be less virulent than the Kikwit strain of EBOV. The applicability of these findings as potential diagnostic and management tools for EVD in humans warrants further investigation.

AB - The Ebola virus (EBOV) outbreak in West Africa during 2013–2016 demonstrated the need to improve Ebola virus disease (EVD) diagnostics and standards of care. This retrospective study compared laboratory values and clinical features of 3 nonhuman primate models of lethal EVD to assess associations with improved survival time. In addition, the study identified laboratory values useful as predictors of survival, surrogates for EBOV viral loads, and triggers for initiation of therapeutic interventions in these nonhuman primate models. Furthermore, the data support that, in nonhuman primates, the Makona strain of EBOV may be less virulent than the Kikwit strain of EBOV. The applicability of these findings as potential diagnostic and management tools for EVD in humans warrants further investigation.

UR - http://www.scopus.com/inward/record.url?scp=85025107816&partnerID=8YFLogxK

U2 - 10.3201/eid2308.170029

DO - 10.3201/eid2308.170029

M3 - Article

C2 - 28726603

AN - SCOPUS:85025107816

SN - 1080-6040

VL - 23

SP - 1316

EP - 1324

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 8

ER -

Clinical laboratory values as early indicators of ebola virus infection in nonhuman primates

Abstract

Access to Document

Fingerprint

Cite this