Clinical presentations for influenza and influenza-like illness in young, immunized soldiers

K. Mills McNeill*, Beverly L. Vaughn, Mary B. Brundage, Yuanzhang Li, Ron K. Poropatich, Joel C. Gaydos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Concern about respiratory diseases in soldiers increased in the late 1990s as production of the successful adenovirus vaccines stopped and the possibilities of an emergent pandemic influenza strain and use of bioweapons by terrorists were seriously considered. Current information on the causes and severity of influenza-like illness (ILI) was lacking. Viral agents and clinical presentations were described in a population of soldiers highly immunized for influenza. Using standard virus isolation techniques, 10 agents were identified in 164 (48.2%) of 340 soldiers hospitalized for ILI. Influenza isolates (29) and adenoviruses (98) occurred most frequently. Most influenza cases were caused by influenza A and probably resulted from a mismatch between circulating and vaccine viruses. Most (58.5%) patients with an adenovirus had a chest radiograph; 31.3% of these had an infiltrate. Clinical findings did not differentiate ILI caused by the various agents. Only 29 cases of influenza occurred in ∼7,200 person-years of observation, supporting the use of influenza vaccine.

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalMilitary Medicine
Issue number1
StatePublished - Jan 2005
Externally publishedYes


Dive into the research topics of 'Clinical presentations for influenza and influenza-like illness in young, immunized soldiers'. Together they form a unique fingerprint.

Cite this