Clinical proteomics and molecular pathology

Lance A. Liotta, Justin B. Davis, Weidong Zhou, Emanuel Petricoin, Virginia Espina, Robin D. Couch, Claudia Fredolini

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Genomic and proteomic research is launching the next era of cancer molecular medicine. Molecular expression profiles can uncover clues to functionally important molecules in the development of human disease and generate information to subclassify human tumors and tailor a treatment to the individual patient. The next revolution is the synthesis of proteomic information into functional pathways and circuits in cells and tissues. Such synthesis must take into account the dynamic state of protein post-translational modifications; protein-protein or protein-DNA/RNA interactions; cross-talk between signal pathways; and feedback regulation within cells, between cells, and between tissues. This full set of information may be required before we can fully dissect the specific dysregulated pathways driving tumorigenesis. This higher level of functional understanding will be the basis for true rational therapeutic design that specifically targets the molecular lesions underlying human disease.

Original languageEnglish
Title of host publicationEssential Concepts in Molecular Pathology
Number of pages15
ISBN (Electronic)9780128132579
ISBN (Print)9780128132586
StatePublished - 1 Jan 2020
Externally publishedYes


  • Analyte
  • Antibody
  • Biomarker
  • Microdissection
  • Proteomics
  • Tumorigenesis


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