Clinical proteomics: Translating benchside promise into bedside reality

Emanuel F. Petricoin*, Kathryn C. Zoon, Elise C. Kohn, J. Carl Barrett, Lance A. Liotta

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

497 Scopus citations

Abstract

The ultimate goal of proteomics is to characterize the information flow through protein networks. This information can be a cause, or a consequence, of disease processes. Clinical proteomics is an exciting new subdiscipline of proteomics that involves the application of proteomic technologies at the bedside, and cancer, in particular, is a model disease for studying such applications. Here, we describe proteomic technologies that are being developed to detect cancer earlier, to discover the next generation of targets and imaging biomarkers, and finally to tailor the therapy to the patient.

Original languageEnglish
Pages (from-to)683-695
Number of pages13
JournalNature Reviews Drug Discovery
Volume1
Issue number9
DOIs
StatePublished - Sep 2002
Externally publishedYes

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