TY - JOUR
T1 - Clinical significance of low molecular weight (7-8s) immunoglobulin M antibody to hepatitis B core antigen in chronic hepatitis B virus infections
AU - Sjogren, Maria H.
AU - Bancroft, William H.
AU - Hoofnagle, Jay H.
AU - Sosebee, James L.
AU - Lemon, Stanley M.
N1 - Funding Information:
Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, DC.; Liver Diseases Section, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland
PY - 1986/7
Y1 - 1986/7
N2 - Separation of 7-8S and 19S forms of serum immunoglobulin M (IgM) hepatitis B core antibody (anti-HBc) by rate-zonal centrifugation was carried out on serum from 80 American chronic carriers of hepatitis B surface antigen (HBsAg), all of whom were positive for IgM anti-HBc and had elevated levels of serum alanine aminotransferase (mean 164 IU/L). Seventy-three of the 80 sera showed a predominance of one or the other form of IgM anti-HBc. Fifty-four (68%) had predominantly 7-8S IgM anti-HBc, and 19 (24%) had predominantly 19S IgM anti-HBc. Sex, age, length of HBsAg-carrier state, mean alanine aminotransferase, mean total IgM anti-HBc level, presence of hepatitis B e antigen, and liver histology were similar in both groups. 19S IgM anti-HBc was detected in 11 (41%) of 27 male homosexuals compared with only 8 (17%) of 46 heterosexual patients (p = 0.03). Despite this apparent association, an explanation for the variable presence of 19S and 7-8S IgM anti-HBc predominance in chronic hepatitis B remains lacking.
AB - Separation of 7-8S and 19S forms of serum immunoglobulin M (IgM) hepatitis B core antibody (anti-HBc) by rate-zonal centrifugation was carried out on serum from 80 American chronic carriers of hepatitis B surface antigen (HBsAg), all of whom were positive for IgM anti-HBc and had elevated levels of serum alanine aminotransferase (mean 164 IU/L). Seventy-three of the 80 sera showed a predominance of one or the other form of IgM anti-HBc. Fifty-four (68%) had predominantly 7-8S IgM anti-HBc, and 19 (24%) had predominantly 19S IgM anti-HBc. Sex, age, length of HBsAg-carrier state, mean alanine aminotransferase, mean total IgM anti-HBc level, presence of hepatitis B e antigen, and liver histology were similar in both groups. 19S IgM anti-HBc was detected in 11 (41%) of 27 male homosexuals compared with only 8 (17%) of 46 heterosexual patients (p = 0.03). Despite this apparent association, an explanation for the variable presence of 19S and 7-8S IgM anti-HBc predominance in chronic hepatitis B remains lacking.
UR - http://www.scopus.com/inward/record.url?scp=0022501719&partnerID=8YFLogxK
U2 - 10.1016/0016-5085(86)90454-3
DO - 10.1016/0016-5085(86)90454-3
M3 - Article
C2 - 3710066
AN - SCOPUS:0022501719
SN - 0016-5085
VL - 91
SP - 168
EP - 173
JO - Gastroenterology
JF - Gastroenterology
IS - 1
ER -