Clinical significance of low molecular weight (7-8s) immunoglobulin M antibody to hepatitis B core antigen in chronic hepatitis B virus infections

Maria H. Sjogren; William H. Bancroft; Jay H. Hoofnagle; James L. Sosebee; Stanley M. Lemon

doi:10.1016/0016-5085(86)90454-3

Clinical significance of low molecular weight (7-8s) immunoglobulin M antibody to hepatitis B core antigen in chronic hepatitis B virus infections

Maria H. Sjogren^*, William H. Bancroft, Jay H. Hoofnagle, James L. Sosebee, Stanley M. Lemon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Separation of 7-8S and 19S forms of serum immunoglobulin M (IgM) hepatitis B core antibody (anti-HBc) by rate-zonal centrifugation was carried out on serum from 80 American chronic carriers of hepatitis B surface antigen (HBsAg), all of whom were positive for IgM anti-HBc and had elevated levels of serum alanine aminotransferase (mean 164 IU/L). Seventy-three of the 80 sera showed a predominance of one or the other form of IgM anti-HBc. Fifty-four (68%) had predominantly 7-8S IgM anti-HBc, and 19 (24%) had predominantly 19S IgM anti-HBc. Sex, age, length of HBsAg-carrier state, mean alanine aminotransferase, mean total IgM anti-HBc level, presence of hepatitis B e antigen, and liver histology were similar in both groups. 19S IgM anti-HBc was detected in 11 (41%) of 27 male homosexuals compared with only 8 (17%) of 46 heterosexual patients (p = 0.03). Despite this apparent association, an explanation for the variable presence of 19S and 7-8S IgM anti-HBc predominance in chronic hepatitis B remains lacking.

Original language	English
Pages (from-to)	168-173
Number of pages	6
Journal	Gastroenterology
Volume	91
Issue number	1
DOIs	https://doi.org/10.1016/0016-5085(86)90454-3
State	Published - Jul 1986

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@article{5d8704bad0c942ce8e8cd0be2ad810ef,

title = "Clinical significance of low molecular weight (7-8s) immunoglobulin M antibody to hepatitis B core antigen in chronic hepatitis B virus infections",

abstract = "Separation of 7-8S and 19S forms of serum immunoglobulin M (IgM) hepatitis B core antibody (anti-HBc) by rate-zonal centrifugation was carried out on serum from 80 American chronic carriers of hepatitis B surface antigen (HBsAg), all of whom were positive for IgM anti-HBc and had elevated levels of serum alanine aminotransferase (mean 164 IU/L). Seventy-three of the 80 sera showed a predominance of one or the other form of IgM anti-HBc. Fifty-four (68%) had predominantly 7-8S IgM anti-HBc, and 19 (24%) had predominantly 19S IgM anti-HBc. Sex, age, length of HBsAg-carrier state, mean alanine aminotransferase, mean total IgM anti-HBc level, presence of hepatitis B e antigen, and liver histology were similar in both groups. 19S IgM anti-HBc was detected in 11 (41%) of 27 male homosexuals compared with only 8 (17%) of 46 heterosexual patients (p = 0.03). Despite this apparent association, an explanation for the variable presence of 19S and 7-8S IgM anti-HBc predominance in chronic hepatitis B remains lacking.",

author = "Sjogren, {Maria H.} and Bancroft, {William H.} and Hoofnagle, {Jay H.} and Sosebee, {James L.} and Lemon, {Stanley M.}",

note = "Funding Information: Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, DC.; Liver Diseases Section, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland",

year = "1986",

month = jul,

doi = "10.1016/0016-5085(86)90454-3",

language = "English",

volume = "91",

pages = "168--173",

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publisher = "W.B. Saunders",

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T1 - Clinical significance of low molecular weight (7-8s) immunoglobulin M antibody to hepatitis B core antigen in chronic hepatitis B virus infections

AU - Sjogren, Maria H.

AU - Bancroft, William H.

AU - Hoofnagle, Jay H.

AU - Sosebee, James L.

AU - Lemon, Stanley M.

N1 - Funding Information: Department of Virus Diseases, Walter Reed Army Institute of Research, Washington, DC.; Liver Diseases Section, National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland

PY - 1986/7

Y1 - 1986/7

N2 - Separation of 7-8S and 19S forms of serum immunoglobulin M (IgM) hepatitis B core antibody (anti-HBc) by rate-zonal centrifugation was carried out on serum from 80 American chronic carriers of hepatitis B surface antigen (HBsAg), all of whom were positive for IgM anti-HBc and had elevated levels of serum alanine aminotransferase (mean 164 IU/L). Seventy-three of the 80 sera showed a predominance of one or the other form of IgM anti-HBc. Fifty-four (68%) had predominantly 7-8S IgM anti-HBc, and 19 (24%) had predominantly 19S IgM anti-HBc. Sex, age, length of HBsAg-carrier state, mean alanine aminotransferase, mean total IgM anti-HBc level, presence of hepatitis B e antigen, and liver histology were similar in both groups. 19S IgM anti-HBc was detected in 11 (41%) of 27 male homosexuals compared with only 8 (17%) of 46 heterosexual patients (p = 0.03). Despite this apparent association, an explanation for the variable presence of 19S and 7-8S IgM anti-HBc predominance in chronic hepatitis B remains lacking.

AB - Separation of 7-8S and 19S forms of serum immunoglobulin M (IgM) hepatitis B core antibody (anti-HBc) by rate-zonal centrifugation was carried out on serum from 80 American chronic carriers of hepatitis B surface antigen (HBsAg), all of whom were positive for IgM anti-HBc and had elevated levels of serum alanine aminotransferase (mean 164 IU/L). Seventy-three of the 80 sera showed a predominance of one or the other form of IgM anti-HBc. Fifty-four (68%) had predominantly 7-8S IgM anti-HBc, and 19 (24%) had predominantly 19S IgM anti-HBc. Sex, age, length of HBsAg-carrier state, mean alanine aminotransferase, mean total IgM anti-HBc level, presence of hepatitis B e antigen, and liver histology were similar in both groups. 19S IgM anti-HBc was detected in 11 (41%) of 27 male homosexuals compared with only 8 (17%) of 46 heterosexual patients (p = 0.03). Despite this apparent association, an explanation for the variable presence of 19S and 7-8S IgM anti-HBc predominance in chronic hepatitis B remains lacking.

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DO - 10.1016/0016-5085(86)90454-3

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Clinical significance of low molecular weight (7-8s) immunoglobulin M antibody to hepatitis B core antigen in chronic hepatitis B virus infections

Abstract

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