Clinical significance of two forms of IgM antibody to hepatitis delta virus

Rosendo Jardi, Maria Buti*, Francisco Rodriguez‐Frias, Ana Garcia‐Lafuente, Maria H. Sjogren, Rafael Esteban, Jaime Guardia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Separation of 7–8 S and 19 S forms of serum IgM antibodies to the hepatitis delta virus by rate‐zonal centrifugation was carried out on serum from 24 patients with hepatitis delta virus infection: 4 patients with acute, self‐limited hepatitis; 5 patients with hepatitis delta virus superinfection progressing to chronicity; and 15 patients with chronic hepatitis delta virus. The high molecular weight IgM form (19 S) was predominantly detected in acute hepatitis delta virus cases, whereas the low molecular weight (7 S) form was found in chronic hepatitis delta virus cases. The serological profile of these two forms of IgM antibody to hepatitis delta virus was investigated in serial samples from five patients with acute hepatitis delta virus superinfection that evolved to chronic hepatitis delta virus. We found that, in the acute stage of the disease, the 19 S form was predominant, whereas 6 mo later a predominance of 7–8 S IgM was observed. These results suggest that IgM antibody to hepatitis delta virus antibody forms are different in acute and chronic hepatitis delta virus infection and that their detection only helps in differentiating an acute infection from a chronic infection but not a hepatitis delta virus—hepatitis B virus.‐HBV coinfection from hepatitis delta virus superinfection in the acute stage of the disease. (HEPATOLOGY 1991;14:25–28.)

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalHepatology
Volume14
Issue number1
DOIs
StatePublished - Jul 1991
Externally publishedYes

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