Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials: Cells, exosomes, and hydrogels

Trivia Frazier; Andrea Alarcon; Xiying Wu; Omair A. Mohiuddin; Jessica M. Motherwell; Anders H. Carlsson; Robert J. Christy; Judson V. Edwards; Robert T. Mackin; Nicolette Prevost; Elena Gloster; Qiang Zhang; Guangdi Wang; Daniel J. Hayes; Jeffrey M. Gimble

doi:10.3390/biom10101373

Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials: Cells, exosomes, and hydrogels

Trivia Frazier^*, Andrea Alarcon, Xiying Wu, Omair A. Mohiuddin, Jessica M. Motherwell, Anders H. Carlsson, Robert J. Christy, Judson V. Edwards, Robert T. Mackin, Nicolette Prevost, Elena Gloster, Qiang Zhang, Guangdi Wang, Daniel J. Hayes, Jeffrey M. Gimble^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose‐, blood‐, and cellulose‐derived products (cells, decellularized matrices and scaffolds, and exosome and secretome factors) as a means to address this unmet medical need. The current status of this research area is evaluated and discussed in the context of promising avenues for future discovery.

Original language	English
Article number	1373
Pages (from-to)	1-21
Number of pages	21
Journal	Biomolecules
Volume	10
Issue number	10
DOIs	https://doi.org/10.3390/biom10101373
State	Published - Oct 2020
Externally published	Yes

Keywords

Adipose‐derived stromal/stem cells (ASC)
Blood
Burns
Cellulose
Exosome
Platelets
Pressure injury
Pressure ulcer
Secretome

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10.3390/biom10101373

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Frazier, T., Alarcon, A., Wu, X., Mohiuddin, O. A., Motherwell, J. M., Carlsson, A. H., Christy, R. J., Edwards, J. V., Mackin, R. T., Prevost, N., Gloster, E., Zhang, Q., Wang, G., Hayes, D. J., & Gimble, J. M. (2020). Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials: Cells, exosomes, and hydrogels. Biomolecules, 10(10), 1-21. Article 1373. https://doi.org/10.3390/biom10101373

@article{396cf9bcfad24fcdab121808e8babedf,

title = "Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials: Cells, exosomes, and hydrogels",

abstract = "Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose‐, blood‐, and cellulose‐derived products (cells, decellularized matrices and scaffolds, and exosome and secretome factors) as a means to address this unmet medical need. The current status of this research area is evaluated and discussed in the context of promising avenues for future discovery.",

keywords = "Adipose‐derived stromal/stem cells (ASC), Blood, Burns, Cellulose, Exosome, Platelets, Pressure injury, Pressure ulcer, Secretome",

author = "Trivia Frazier and Andrea Alarcon and Xiying Wu and Mohiuddin, {Omair A.} and Motherwell, {Jessica M.} and Carlsson, {Anders H.} and Christy, {Robert J.} and Edwards, {Judson V.} and Mackin, {Robert T.} and Nicolette Prevost and Elena Gloster and Qiang Zhang and Guangdi Wang and Hayes, {Daniel J.} and Gimble, {Jeffrey M.}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = oct,

doi = "10.3390/biom10101373",

language = "English",

volume = "10",

pages = "1--21",

journal = "Biomolecules",

issn = "2218-273X",

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}

Frazier, T, Alarcon, A, Wu, X, Mohiuddin, OA, Motherwell, JM, Carlsson, AH, Christy, RJ, Edwards, JV, Mackin, RT, Prevost, N, Gloster, E, Zhang, Q, Wang, G, Hayes, DJ & Gimble, JM 2020, 'Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials: Cells, exosomes, and hydrogels', Biomolecules, vol. 10, no. 10, 1373, pp. 1-21. https://doi.org/10.3390/biom10101373

TY - JOUR

T1 - Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials

T2 - Cells, exosomes, and hydrogels

AU - Frazier, Trivia

AU - Alarcon, Andrea

AU - Wu, Xiying

AU - Mohiuddin, Omair A.

AU - Motherwell, Jessica M.

AU - Carlsson, Anders H.

AU - Christy, Robert J.

AU - Edwards, Judson V.

AU - Mackin, Robert T.

AU - Prevost, Nicolette

AU - Gloster, Elena

AU - Zhang, Qiang

AU - Wang, Guangdi

AU - Hayes, Daniel J.

AU - Gimble, Jeffrey M.

PY - 2020/10

Y1 - 2020/10

N2 - Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose‐, blood‐, and cellulose‐derived products (cells, decellularized matrices and scaffolds, and exosome and secretome factors) as a means to address this unmet medical need. The current status of this research area is evaluated and discussed in the context of promising avenues for future discovery.

AB - Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose‐, blood‐, and cellulose‐derived products (cells, decellularized matrices and scaffolds, and exosome and secretome factors) as a means to address this unmet medical need. The current status of this research area is evaluated and discussed in the context of promising avenues for future discovery.

KW - Adipose‐derived stromal/stem cells (ASC)

KW - Blood

KW - Burns

KW - Cellulose

KW - Exosome

KW - Platelets

KW - Pressure injury

KW - Pressure ulcer

KW - Secretome

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U2 - 10.3390/biom10101373

DO - 10.3390/biom10101373

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AN - SCOPUS:85091634964

SN - 2218-273X

VL - 10

SP - 1

EP - 21

JO - Biomolecules

JF - Biomolecules

IS - 10

M1 - 1373

ER -

Clinical translational potential in skin wound regeneration for adipose‐derived, blood‐derived, and cellulose materials: Cells, exosomes, and hydrogels

Abstract

Keywords

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