Clonal distribution and associated characteristics of Escherichia coli clinical and surveillance isolates from a military medical center

Amee R. Manges, Katrin Mende, Clinton K. Murray, Brian D. Johnston, Evgeni V. Sokurenko, Veronika Tchesnokova, James R. Johnson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Antimicrobial-resistant Escherichia coli are a concern for military health services. We studied 100 extended-spectrum beta-lactamase (ESBL)-producing and non-producing E. coli clinical and surveillance isolates from military personnel and civilians at Brooke Army Medical Center (2007–2011). Major E. coli lineages, most prominently ST10 (24%), ST131 (16%), and ST648 (8%), were distributed much as reported for other North American populations. ST131, represented mainly by its resistance-associated ST131-H30 clonal subset, was uniquely associated with a clinical origin, regardless of ESBL status. Thus, clonal background predicted resistance phenotype and clinical versus surveillance origin, and these findings could assist military clinicians and epidemiologists.

Original languageEnglish
Pages (from-to)382-385
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume87
Issue number4
DOIs
StatePublished - 1 Apr 2017

Keywords

  • Antimicrobial resistance
  • Escherichia coli infections
  • Extended-spectrum beta-lactamases
  • Military medicine
  • Molecular epidemiology
  • Multilocus sequence typing
  • ST131
  • ST131-H30
  • Veterans
  • Virulence genes

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