Clonidine suppression testing for pheochromocytoma in neurofibromatosis type 1

Wingyee Wan*, Bichle Nguyen, Sky Graybill, Jonathan Kim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Compared with the general population, rates of pheochromocytoma are higher in neurofibromatosis type 1 (NF1) patients. However, pheochromocytoma testing is often plagued by false positive results. Here we present a patient with NF1, elevated urinary metanephrine levels, and an indeterminate adrenal nodule. Clonidine suppression testing aided diagnosis and led to definitive surgical treatment that confirmed a pheochromocytoma. Pheochromocytoma screening and clonidine suppression testing can both aid in the evaluation for catecholamine-secreting tumours.

Original languageEnglish
Article numbere228263
JournalBMJ Case Reports
Issue number6
StatePublished - 1 Jun 2019
Externally publishedYes


  • Adrenal disorders
  • Neuro genetics


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