Coagulation During Hypothermia in Man

John P. Bunker, Robert Goldstein

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Clotting times, platelets, thromboplastin generation, prothrombin consumption, prothrombin time, and concentrations of prothrombin, accelerator globulin, proconvertin, and fibrinogen were measured in 10 patients after the slow induction of hypothermia and later during surgery and transfusion. In contrast to previous studies in the dog, uncomplicated hypothermia in man was not associated with a fall in concentration of clotting factors. Moderate disturbances in coagulation with surgery and transfusion during hypothermia were in most regards similar to those observed during surgery and transfusion at normal body temperature. The one significant difference was a decrease in prothrombin consumption.

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - Jan 1958
Externally publishedYes


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