Evidence-Based Answer Compared with placebo, celecoxib improves pain (number needed to treat [NNT]= 4) and clinical symptoms (NNT= 7), but it has no effect on physical function in patients with RA. 1 (Strength of Recommendation [SOR]= A, based on moderate-quality evidence.) Compared with traditional nonsteroidal anti-inflammatory drugs (NSAIDs), celecoxib is no better at improving pain or physical function in patients with RA. Celecoxib causes fewer gastroduodenal ulcers (at least 3 mm in size) than traditional NSAIDs (number needed to harm [NNH] with traditional NSAIDs as opposed to celecoxib= 9). 1 (SOR= A, based on moderate-quality evidence.) Practice Pointers RA is a common type of inflammatory arthritis.[...] fewer patients discontinued celecoxib therapy (7%) than traditional NSAID therapy (14%; absolute change= 7%; 95% CI, 4% to 9%; NNH= 14 [95% CI, 11 to 23]).
|Original language||American English|
|Journal||American Family Physician|
|State||Published - 1 May 2018|