TY - JOUR
T1 - Cold-stored platelets
T2 - A product with function optimized for hemorrhage control
AU - Reddoch-Cardenas, K. M.
AU - Bynum, J. A.
AU - Meledeo, M. A.
AU - Nair, P. M.
AU - Wu, X.
AU - Darlington, D. N.
AU - Ramasubramanian, A. K.
AU - Cap, A. P.
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/2
Y1 - 2019/2
N2 - Early administration of blood products following severe trauma is pivotal for establishing hemostasis and achieving successful outcomes. Platelet transfusions, in particular, provide rapid control of hemostasis and help to restore platelet dysfunction induced by trauma. In the U.S. platelets used for therapeutic purposes are stored at room temperature with a limited shelf life of 5-7 days. Issues with room temperature storage of platelets, including an increased risk of bacterial growth and a decline in platelet hemostatic function, have led to a resurgence in interest in cold-stored platelets for therapeutic transfusion. This review presents the current state of cold-stored platelets and cold-stored whole blood as treatment for actively bleeding patients. Usage of cold stored platelets in alternative areas, such as in the field of regenerative medicine, is also discussed.
AB - Early administration of blood products following severe trauma is pivotal for establishing hemostasis and achieving successful outcomes. Platelet transfusions, in particular, provide rapid control of hemostasis and help to restore platelet dysfunction induced by trauma. In the U.S. platelets used for therapeutic purposes are stored at room temperature with a limited shelf life of 5-7 days. Issues with room temperature storage of platelets, including an increased risk of bacterial growth and a decline in platelet hemostatic function, have led to a resurgence in interest in cold-stored platelets for therapeutic transfusion. This review presents the current state of cold-stored platelets and cold-stored whole blood as treatment for actively bleeding patients. Usage of cold stored platelets in alternative areas, such as in the field of regenerative medicine, is also discussed.
KW - Cold stored platelets
KW - Cold stored whole blood
KW - Platelet transfusion
KW - Therapeutic transfusion
UR - http://www.scopus.com/inward/record.url?scp=85060543482&partnerID=8YFLogxK
U2 - 10.1016/j.transci.2018.12.012
DO - 10.1016/j.transci.2018.12.012
M3 - Review article
C2 - 30704925
AN - SCOPUS:85060543482
SN - 1473-0502
VL - 58
SP - 16
EP - 22
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
IS - 1
ER -