Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics

Aaron R. Farmer*, Clinton K. Murray, Ian R. Driscoll, Brian L. Wickes, Nathan Wiederhold, Deanna A. Sutton, Carmita Sanders, Katrin Mende, Brent Enniss, James Feig, Anuradha Ganesan, Elizabeth A. Rini, Todd J. Vento

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence-and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.

Original languageEnglish
Pages (from-to)1968-1975
Number of pages8
JournalJournal of Clinical Microbiology
Volume53
Issue number6
DOIs
StatePublished - 1 Jun 2015
Externally publishedYes

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