Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics

Aaron R. Farmer; Clinton K. Murray; Ian R. Driscoll; Brian L. Wickes; Nathan Wiederhold; Deanna A. Sutton; Carmita Sanders; Katrin Mende; Brent Enniss; James Feig; Anuradha Ganesan; Elizabeth A. Rini; Todd J. Vento

doi:10.1128/JCM.00410-15

Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics

Aaron R. Farmer^*, Clinton K. Murray, Ian R. Driscoll, Brian L. Wickes, Nathan Wiederhold, Deanna A. Sutton, Carmita Sanders, Katrin Mende, Brent Enniss, James Feig, Anuradha Ganesan, Elizabeth A. Rini, Todd J. Vento

^*Corresponding author for this work

Medicine

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Abstract

We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence-and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.

Original language	English
Pages (from-to)	1968-1975
Number of pages	8
Journal	Journal of Clinical Microbiology
Volume	53
Issue number	6
DOIs	https://doi.org/10.1128/JCM.00410-15
State	Published - 1 Jun 2015

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Farmer, A. R., Murray, C. K., Driscoll, I. R., Wickes, B. L., Wiederhold, N., Sutton, D. A., Sanders, C., Mende, K., Enniss, B., Feig, J., Ganesan, A., Rini, E. A., & Vento, T. J. (2015). Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics. Journal of Clinical Microbiology, 53(6), 1968-1975. https://doi.org/10.1128/JCM.00410-15

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abstract = "We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence-and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.",

author = "Farmer, {Aaron R.} and Murray, {Clinton K.} and Driscoll, {Ian R.} and Wickes, {Brian L.} and Nathan Wiederhold and Sutton, {Deanna A.} and Carmita Sanders and Katrin Mende and Brent Enniss and James Feig and Anuradha Ganesan and Rini, {Elizabeth A.} and Vento, {Todd J.}",

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Farmer, AR, Murray, CK, Driscoll, IR, Wickes, BL, Wiederhold, N, Sutton, DA, Sanders, C, Mende, K, Enniss, B, Feig, J, Ganesan, A, Rini, EA & Vento, TJ 2015, 'Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics', Journal of Clinical Microbiology, vol. 53, no. 6, pp. 1968-1975. https://doi.org/10.1128/JCM.00410-15

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AU - Farmer, Aaron R.

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AU - Wickes, Brian L.

AU - Wiederhold, Nathan

AU - Sutton, Deanna A.

AU - Sanders, Carmita

AU - Mende, Katrin

AU - Enniss, Brent

AU - Feig, James

AU - Ganesan, Anuradha

AU - Rini, Elizabeth A.

AU - Vento, Todd J.

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AB - We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence-and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.

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EP - 1975

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 6

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Combat-related pythium aphanidermatum invasive wound infection: Case report and discussion of utility of molecular diagnostics

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