Combinatorial Immunotherapy and Chemotherapy

Christin B. DeStefano, Stephen V. Liu*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


Immunotherapy has emerged as an effective strategy in several cancer types that, unlike most conventional therapies, can deliver durable disease control with a favorable toxicity profile. In an unselected population, however, the majority of patients will not respond. Combining immunotherapy with other treatment modalities may increase the likelihood and potentially the depth of response. One approach is to combine immunotherapy with cytotoxic chemotherapy. There are both potential benefits and limitations to this approach, and while early data are encouraging, more work is needed to optimize these combinations and clearly define their role in the therapeutic landscape.

Original languageEnglish
Title of host publicationCurrent Cancer Research
PublisherSpringer Nature
Number of pages20
StatePublished - 2018
Externally publishedYes

Publication series

NameCurrent Cancer Research
ISSN (Print)2199-2584
ISSN (Electronic)2199-2592


  • Checkpoint inhibitors
  • Chemoimmunotherapy
  • Chemotherapy
  • Combination
  • Immunotherapy


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