Common Challenges in Tissue Regeneration

Jonas Eriksson; William D’Angelo; Stephen F. Badylak

doi:10.1016/B978-0-12-814879-2.00009-1

Common Challenges in Tissue Regeneration

Jonas Eriksson, William D’Angelo, Stephen F. Badylak

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

The past three decades have seen a marked expansion of research into the biology of regeneration, and the goals of tissue engineering/regenerative medicine (TE/RM) continue to move closer to realization. However, progress toward clinical translation of TE/RM strategies has been slower than anticipated. Several significant hurdles remain, both in the form of technical challenges as well as gaps in basic understanding of the biological mechanisms of regeneration. In the present chapter, several of these barriers are identified, including the difficulty of choosing the source of cells for TE/RM therapies, problems associated with the artificial environment of in vitro cell culture, immunologic barriers, and low engraftment and survival of implanted cells.

Original language	English
Title of host publication	Epigenetics and Regeneration
Publisher	Elsevier
Pages	217-229
Number of pages	13
ISBN (Electronic)	9780128148792
DOIs	https://doi.org/10.1016/B978-0-12-814879-2.00009-1
State	Published - 1 Jan 2019
Externally published	Yes

Keywords

Damage-associated molecular patterns
Epigenetics
Extracellular matrix
Immune system
Pathogen-associated molecular patterns
Regenerative medicine
Tissue engineering
Transflammation

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10.1016/B978-0-12-814879-2.00009-1

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title = "Common Challenges in Tissue Regeneration",

abstract = "The past three decades have seen a marked expansion of research into the biology of regeneration, and the goals of tissue engineering/regenerative medicine (TE/RM) continue to move closer to realization. However, progress toward clinical translation of TE/RM strategies has been slower than anticipated. Several significant hurdles remain, both in the form of technical challenges as well as gaps in basic understanding of the biological mechanisms of regeneration. In the present chapter, several of these barriers are identified, including the difficulty of choosing the source of cells for TE/RM therapies, problems associated with the artificial environment of in vitro cell culture, immunologic barriers, and low engraftment and survival of implanted cells.",

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AU - D’Angelo, William

AU - Badylak, Stephen F.

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N2 - The past three decades have seen a marked expansion of research into the biology of regeneration, and the goals of tissue engineering/regenerative medicine (TE/RM) continue to move closer to realization. However, progress toward clinical translation of TE/RM strategies has been slower than anticipated. Several significant hurdles remain, both in the form of technical challenges as well as gaps in basic understanding of the biological mechanisms of regeneration. In the present chapter, several of these barriers are identified, including the difficulty of choosing the source of cells for TE/RM therapies, problems associated with the artificial environment of in vitro cell culture, immunologic barriers, and low engraftment and survival of implanted cells.

AB - The past three decades have seen a marked expansion of research into the biology of regeneration, and the goals of tissue engineering/regenerative medicine (TE/RM) continue to move closer to realization. However, progress toward clinical translation of TE/RM strategies has been slower than anticipated. Several significant hurdles remain, both in the form of technical challenges as well as gaps in basic understanding of the biological mechanisms of regeneration. In the present chapter, several of these barriers are identified, including the difficulty of choosing the source of cells for TE/RM therapies, problems associated with the artificial environment of in vitro cell culture, immunologic barriers, and low engraftment and survival of implanted cells.

KW - Damage-associated molecular patterns

KW - Epigenetics

KW - Extracellular matrix

KW - Immune system

KW - Pathogen-associated molecular patterns

KW - Regenerative medicine

KW - Tissue engineering

KW - Transflammation

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M3 - Chapter

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SP - 217

EP - 229

BT - Epigenetics and Regeneration

PB - Elsevier

ER -

Common Challenges in Tissue Regeneration

Abstract

Keywords

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