Common Patterns and Unique Threats in Antimicrobial Resistance as Revealed by Global Gonococcal Surveillance, 2014-2022

Luz Angela Van; Nazia Rahman; Reuel Sandy; Nelson Dozier; Hunter J. Smith; Melissa J. Martin; Katelyn V. Bartlett; Krit Harncharoenkul; Anna Nanava; Tamar Akhvlediani; Paul Rios; Supriya D. Mehta; Walter Agingu; Denis K. Byarugaba; Fred Wabwire-Mangen; Hannah Kibuuka; Bernard Erima; Hope O. Kabatasi; Naiki Attram; Dutsadee Peerapongpaisarn; Wilawan Oransathit; Wirote Oransathit; Umaporn Suksawad; Woradee Lurchachaiwong; Somchai Sriplienchan; Nonlawat Boonyalai; Maneerat Somsri; Nithinart Chaitaveep; Ann Jerse; Eric Garges

doi:10.3201/eid3014.240296

Common Patterns and Unique Threats in Antimicrobial Resistance as Revealed by Global Gonococcal Surveillance, 2014-2022

Luz Angela Van^*, Nazia Rahman, Reuel Sandy, Nelson Dozier, Hunter J. Smith, Melissa J. Martin, Katelyn V. Bartlett, Krit Harncharoenkul, Anna Nanava, Tamar Akhvlediani, Paul Rios, Supriya D. Mehta, Walter Agingu, Denis K. Byarugaba, Fred Wabwire-Mangen, Hannah Kibuuka, Bernard Erima, Hope O. Kabatasi, Naiki Attram, Dutsadee PeerapongpaisarnWilawan Oransathit, Wirote Oransathit, Umaporn Suksawad, Woradee Lurchachaiwong, Somchai Sriplienchan, Nonlawat Boonyalai, Maneerat Somsri, Nithinart Chaitaveep, Ann Jerse, Eric Garges

^*Corresponding author for this work

Global Public Health

Research output: Contribution to journal › Article › peer-review

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Abstract

The rapid emergence of antimicrobial-resistant strains of Neisseria gonorrhoeae threatens treatment options and control efforts. The Uniformed Services University Gonococcal Reference Laboratory and Repository of the Global Emerging Infections Surveillance Program receives isolates from several geographically distinct regions worldwide. We analyzed 962 isolates collected during 2014-2022 for genomic and phenotypic antimicrobial resistance. Resistance to antimicrobial drugs previously used for gonococcal infections was high, but of most concern were increases of resistance to currently used antibiotic drugs, such as extended-spectrum cephalosporins and the alternative antibiotic treatment gentamicin. The percentage of isolates with reduced susceptibility to ceftriaxone was 3.6%, to cefixime was 2.5%, and to gentamicin was 15.0%. Although isolates were collected from populations of limited diversity, 706 (73.4%) of isolates demonstrated novel multiantigen sequence types, and 225 (23.4%) had novel multilocus sequence types. Continued surveillance of N. gonorrhoeae is essential to monitoring the prevalence and spread of resistant organisms worldwide.

Original language	English
Pages (from-to)	S62-S70
Journal	Emerging Infectious Diseases
Volume	30
Issue number	14
DOIs	https://doi.org/10.3201/eid3014.240296
State	Published - Nov 2024

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Van, L. A., Rahman, N., Sandy, R., Dozier, N., Smith, H. J., Martin, M. J., Bartlett, K. V., Harncharoenkul, K., Nanava, A., Akhvlediani, T., Rios, P., Mehta, S. D., Agingu, W., Byarugaba, D. K., Wabwire-Mangen, F., Kibuuka, H., Erima, B., Kabatasi, H. O., Attram, N., ... Garges, E. (2024). Common Patterns and Unique Threats in Antimicrobial Resistance as Revealed by Global Gonococcal Surveillance, 2014-2022. Emerging Infectious Diseases, 30(14), S62-S70. https://doi.org/10.3201/eid3014.240296

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title = "Common Patterns and Unique Threats in Antimicrobial Resistance as Revealed by Global Gonococcal Surveillance, 2014-2022",

abstract = "The rapid emergence of antimicrobial-resistant strains of Neisseria gonorrhoeae threatens treatment options and control efforts. The Uniformed Services University Gonococcal Reference Laboratory and Repository of the Global Emerging Infections Surveillance Program receives isolates from several geographically distinct regions worldwide. We analyzed 962 isolates collected during 2014-2022 for genomic and phenotypic antimicrobial resistance. Resistance to antimicrobial drugs previously used for gonococcal infections was high, but of most concern were increases of resistance to currently used antibiotic drugs, such as extended-spectrum cephalosporins and the alternative antibiotic treatment gentamicin. The percentage of isolates with reduced susceptibility to ceftriaxone was 3.6%, to cefixime was 2.5%, and to gentamicin was 15.0%. Although isolates were collected from populations of limited diversity, 706 (73.4%) of isolates demonstrated novel multiantigen sequence types, and 225 (23.4%) had novel multilocus sequence types. Continued surveillance of N. gonorrhoeae is essential to monitoring the prevalence and spread of resistant organisms worldwide.",

author = "Van, {Luz Angela} and Nazia Rahman and Reuel Sandy and Nelson Dozier and Smith, {Hunter J.} and Martin, {Melissa J.} and Bartlett, {Katelyn V.} and Krit Harncharoenkul and Anna Nanava and Tamar Akhvlediani and Paul Rios and Mehta, {Supriya D.} and Walter Agingu and Byarugaba, {Denis K.} and Fred Wabwire-Mangen and Hannah Kibuuka and Bernard Erima and Kabatasi, {Hope O.} and Naiki Attram and Dutsadee Peerapongpaisarn and Wilawan Oransathit and Wirote Oransathit and Umaporn Suksawad and Woradee Lurchachaiwong and Somchai Sriplienchan and Nonlawat Boonyalai and Maneerat Somsri and Nithinart Chaitaveep and Ann Jerse and Eric Garges",

year = "2024",

month = nov,

doi = "10.3201/eid3014.240296",

language = "English",

volume = "30",

pages = "S62--S70",

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Van, LA, Rahman, N, Sandy, R, Dozier, N, Smith, HJ, Martin, MJ, Bartlett, KV, Harncharoenkul, K, Nanava, A, Akhvlediani, T, Rios, P, Mehta, SD, Agingu, W, Byarugaba, DK, Wabwire-Mangen, F, Kibuuka, H, Erima, B, Kabatasi, HO, Attram, N, Peerapongpaisarn, D, Oransathit, W, Oransathit, W, Suksawad, U, Lurchachaiwong, W, Sriplienchan, S, Boonyalai, N, Somsri, M, Chaitaveep, N, Jerse, A & Garges, E 2024, 'Common Patterns and Unique Threats in Antimicrobial Resistance as Revealed by Global Gonococcal Surveillance, 2014-2022', Emerging Infectious Diseases, vol. 30, no. 14, pp. S62-S70. https://doi.org/10.3201/eid3014.240296

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T1 - Common Patterns and Unique Threats in Antimicrobial Resistance as Revealed by Global Gonococcal Surveillance, 2014-2022

AU - Van, Luz Angela

AU - Rahman, Nazia

AU - Sandy, Reuel

AU - Dozier, Nelson

AU - Smith, Hunter J.

AU - Martin, Melissa J.

AU - Bartlett, Katelyn V.

AU - Harncharoenkul, Krit

AU - Nanava, Anna

AU - Akhvlediani, Tamar

AU - Rios, Paul

AU - Mehta, Supriya D.

AU - Agingu, Walter

AU - Byarugaba, Denis K.

AU - Wabwire-Mangen, Fred

AU - Kibuuka, Hannah

AU - Erima, Bernard

AU - Kabatasi, Hope O.

AU - Attram, Naiki

AU - Peerapongpaisarn, Dutsadee

AU - Oransathit, Wilawan

AU - Oransathit, Wirote

AU - Suksawad, Umaporn

AU - Lurchachaiwong, Woradee

AU - Sriplienchan, Somchai

AU - Boonyalai, Nonlawat

AU - Somsri, Maneerat

AU - Chaitaveep, Nithinart

AU - Jerse, Ann

AU - Garges, Eric

PY - 2024/11

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N2 - The rapid emergence of antimicrobial-resistant strains of Neisseria gonorrhoeae threatens treatment options and control efforts. The Uniformed Services University Gonococcal Reference Laboratory and Repository of the Global Emerging Infections Surveillance Program receives isolates from several geographically distinct regions worldwide. We analyzed 962 isolates collected during 2014-2022 for genomic and phenotypic antimicrobial resistance. Resistance to antimicrobial drugs previously used for gonococcal infections was high, but of most concern were increases of resistance to currently used antibiotic drugs, such as extended-spectrum cephalosporins and the alternative antibiotic treatment gentamicin. The percentage of isolates with reduced susceptibility to ceftriaxone was 3.6%, to cefixime was 2.5%, and to gentamicin was 15.0%. Although isolates were collected from populations of limited diversity, 706 (73.4%) of isolates demonstrated novel multiantigen sequence types, and 225 (23.4%) had novel multilocus sequence types. Continued surveillance of N. gonorrhoeae is essential to monitoring the prevalence and spread of resistant organisms worldwide.

AB - The rapid emergence of antimicrobial-resistant strains of Neisseria gonorrhoeae threatens treatment options and control efforts. The Uniformed Services University Gonococcal Reference Laboratory and Repository of the Global Emerging Infections Surveillance Program receives isolates from several geographically distinct regions worldwide. We analyzed 962 isolates collected during 2014-2022 for genomic and phenotypic antimicrobial resistance. Resistance to antimicrobial drugs previously used for gonococcal infections was high, but of most concern were increases of resistance to currently used antibiotic drugs, such as extended-spectrum cephalosporins and the alternative antibiotic treatment gentamicin. The percentage of isolates with reduced susceptibility to ceftriaxone was 3.6%, to cefixime was 2.5%, and to gentamicin was 15.0%. Although isolates were collected from populations of limited diversity, 706 (73.4%) of isolates demonstrated novel multiantigen sequence types, and 225 (23.4%) had novel multilocus sequence types. Continued surveillance of N. gonorrhoeae is essential to monitoring the prevalence and spread of resistant organisms worldwide.

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