Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Adam C. Naj; Gyungah Jun; Gary W. Beecham; Li San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J. Gallins; Joseph D. Buxbaum; Gail P. Jarvik; Paul K. Crane; Eric B. Larson; Thomas D. Bird; Bradley F. Boeve; Neill R. Graff-Radford; Philip L. De Jager; Denis Evans; Julie A. Schneider; Minerva M. Carrasquillo; Nilufer Ertekin-Taner; Steven G. Younkin; Carlos Cruchaga; John S.K. Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew J. Huentelman; Amanda J. Myers; Michael M. Barmada; F. Yesim Demirci; Clinton T. Baldwin; Robert C. Green; Ekaterina Rogaeva; Peter St George-Hyslop; Steven E. Arnold; Robert Barber; Thomas Beach; Eileen H. Bigio; James D. Bowen; Adam Boxer; James R. Burke; Nigel J. Cairns; Chris S. Carlson; Regina M. Carney; Steven L. Carroll; Helena C. Chui; David G. Clark; Jason Corneveaux; Carl W. Cotman; Jeffrey L. Cummings; Charles Decarli; Steven T. Dekosky; Ramon Diaz-Arrastia; Malcolm Dick; Dennis W. Dickson; William G. Ellis; Kelley M. Faber; Kenneth B. Fallon; Martin R. Farlow; Steven Ferris; Matthew P. Frosch; Douglas R. Galasko; Mary Ganguli; Marla Gearing; Daniel H. Geschwind; Bernardino Ghetti; John R. Gilbert; Sid Gilman; Bruno Giordani; Jonathan D. Glass; John H. Growdon; Ronald L. Hamilton; Lindy E. Harrell; Elizabeth Head; Lawrence S. Honig; Christine M. Hulette; Bradley T. Hyman; Gregory A. Jicha; Lee Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A. Kaye; Ronald Kim; Edward H. Koo; Neil W. Kowall; James J. Lah; Allan I. Levey; Andrew P. Lieberman; Oscar L. Lopez; Wendy J. MacK; Daniel C. Marson; Frank Martiniuk; Deborah C. Mash; Eliezer Masliah; Wayne C. McCormick; Susan M. McCurry; Andrew N. McDavid; Ann C. McKee; Marsel Mesulam; Bruce L. Miller; Carol A. Miller; Joshua W. Miller; Joseph E. Parisi; Daniel P. Perl; Elaine Peskind; Ronald C. Petersen; Wayne W. Poon; Joseph F. Quinn; Ruchita A. Rajbhandary; Murray Raskind; Barry Reisberg; John M. Ringman; Erik D. Roberson; Roger N. Rosenberg; Mary Sano; Lon S. Schneider; William Seeley; Michael L. Shelanski; Michael A. Slifer; Charles D. Smith; Joshua A. Sonnen; Salvatore Spina; Robert A. Stern; Rudolph E. Tanzi; John Q. Trojanowski; Juan C. Troncoso; Vivianna M. Van Deerlin; Harry V. Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A. Welsh-Bohmer; Jennifer Williamson; Randall L. Woltjer; Laura B. Cantwell; Beth A. Dombroski; Duane Beekly; Kathryn L. Lunetta; Eden R. Martin; M. Ilyas Kamboh; Andrew J. Saykin; Eric M. Reiman; David A. Bennett; John C. Morris; Thomas J. Montine; Alison M. Goate; Deborah Blacker; Debby W. Tsuang; Hakon Hakonarson; Walter A. Kukull; Tatiana M. Foroud; Jonathan L. Haines; Richard Mayeux; Margaret A. Pericak-Vance; Lindsay A. Farrer; Gerard D. Schellenberg

doi:10.1038/ng.801

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Adam C. Naj, Gyungah Jun, Gary W. Beecham, Li San Wang, Badri Narayan Vardarajan, Jacqueline Buros, Paul J. Gallins, Joseph D. Buxbaum, Gail P. Jarvik, Paul K. Crane, Eric B. Larson, Thomas D. Bird, Bradley F. Boeve, Neill R. Graff-Radford, Philip L. De Jager, Denis Evans, Julie A. Schneider, Minerva M. Carrasquillo, Nilufer Ertekin-Taner, Steven G. YounkinCarlos Cruchaga, John S.K. Kauwe, Petra Nowotny, Patricia Kramer, John Hardy, Matthew J. Huentelman, Amanda J. Myers, Michael M. Barmada, F. Yesim Demirci, Clinton T. Baldwin, Robert C. Green, Ekaterina Rogaeva, Peter St George-Hyslop, Steven E. Arnold, Robert Barber, Thomas Beach, Eileen H. Bigio, James D. Bowen, Adam Boxer, James R. Burke, Nigel J. Cairns, Chris S. Carlson, Regina M. Carney, Steven L. Carroll, Helena C. Chui, David G. Clark, Jason Corneveaux, Carl W. Cotman, Jeffrey L. Cummings, Charles Decarli, Steven T. Dekosky, Ramon Diaz-Arrastia, Malcolm Dick, Dennis W. Dickson, William G. Ellis, Kelley M. Faber, Kenneth B. Fallon, Martin R. Farlow, Steven Ferris, Matthew P. Frosch, Douglas R. Galasko, Mary Ganguli, Marla Gearing, Daniel H. Geschwind, Bernardino Ghetti, John R. Gilbert, Sid Gilman, Bruno Giordani, Jonathan D. Glass, John H. Growdon, Ronald L. Hamilton, Lindy E. Harrell, Elizabeth Head, Lawrence S. Honig, Christine M. Hulette, Bradley T. Hyman, Gregory A. Jicha, Lee Way Jin, Nancy Johnson, Jason Karlawish, Anna Karydas, Jeffrey A. Kaye, Ronald Kim, Edward H. Koo, Neil W. Kowall, James J. Lah, Allan I. Levey, Andrew P. Lieberman, Oscar L. Lopez, Wendy J. MacK, Daniel C. Marson, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, Wayne C. McCormick, Susan M. McCurry, Andrew N. McDavid, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Joseph E. Parisi, Daniel P. Perl, Elaine Peskind, Ronald C. Petersen, Wayne W. Poon, Joseph F. Quinn, Ruchita A. Rajbhandary, Murray Raskind, Barry Reisberg, John M. Ringman, Erik D. Roberson, Roger N. Rosenberg, Mary Sano, Lon S. Schneider, William Seeley, Michael L. Shelanski, Michael A. Slifer, Charles D. Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Rudolph E. Tanzi, John Q. Trojanowski, Juan C. Troncoso, Vivianna M. Van Deerlin, Harry V. Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A. Welsh-Bohmer, Jennifer Williamson, Randall L. Woltjer, Laura B. Cantwell, Beth A. Dombroski, Duane Beekly, Kathryn L. Lunetta, Eden R. Martin, M. Ilyas Kamboh, Andrew J. Saykin, Eric M. Reiman, David A. Bennett, John C. Morris, Thomas J. Montine, Alison M. Goate, Deborah Blacker, Debby W. Tsuang, Hakon Hakonarson, Walter A. Kukull, Tatiana M. Foroud, Jonathan L. Haines, Richard Mayeux, Margaret A. Pericak-Vance, Lindsay A. Farrer, Gerard D. Schellenberg

Pathology

Research output: Contribution to journal › Article › peer-review

1673 Scopus citations

Abstract

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P M) = 1.7 × 10 ^-9, joint analysis P (P J) = 1.7 × 10 ^-9; stages 1, 2 and 3, P M = 8.2 × 10 ^-12), CD2AP (rs9349407; stages 1, 2 and 3, P M = 8.6 × 10 ^-9), EPHA1 (rs11767557; stages 1, 2 and 3, P M = 6.0 × 10 ^-10) and CD33 (rs3865444; stages 1, 2 and 3, P M = 1.6 × 10 ^-9). We also replicated previous associations at CR1 (rs6701713; P M = 4.6 × 10 ^-10, P J = 5.2 × 10 ^-11), CLU (rs1532278; P M = 8.3 × 10 ^-8, P J = 1.9 × 10 ^-8), BIN1 (rs7561528; P M = 4.0 × 10 ^-14, P J = 5.2 × 10 ^-14) and PICALM (rs561655; P M = 7.0 × 10 ^-11, P J = 1.0 × 10 ^-10), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.

Original language	English
Pages (from-to)	436-443
Number of pages	8
Journal	Nature Genetics
Volume	43
Issue number	5
DOIs	https://doi.org/10.1038/ng.801
State	Published - May 2011

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10.1038/ng.801

Cite this

Naj, A. C., Jun, G., Beecham, G. W., Wang, L. S., Vardarajan, B. N., Buros, J., Gallins, P. J., Buxbaum, J. D., Jarvik, G. P., Crane, P. K., Larson, E. B., Bird, T. D., Boeve, B. F., Graff-Radford, N. R., De Jager, P. L., Evans, D., Schneider, J. A., Carrasquillo, M. M., Ertekin-Taner, N., ... Schellenberg, G. D. (2011). Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics, 43(5), 436-443. https://doi.org/10.1038/ng.801

@article{a1ba0e4130654eb5ba69236bc851c67a,

title = "Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease",

abstract = "The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P M) = 1.7 × 10 -9, joint analysis P (P J) = 1.7 × 10 -9; stages 1, 2 and 3, P M = 8.2 × 10 -12), CD2AP (rs9349407; stages 1, 2 and 3, P M = 8.6 × 10 -9), EPHA1 (rs11767557; stages 1, 2 and 3, P M = 6.0 × 10 -10) and CD33 (rs3865444; stages 1, 2 and 3, P M = 1.6 × 10 -9). We also replicated previous associations at CR1 (rs6701713; P M = 4.6 × 10 -10, P J = 5.2 × 10 -11), CLU (rs1532278; P M = 8.3 × 10 -8, P J = 1.9 × 10 -8), BIN1 (rs7561528; P M = 4.0 × 10 -14, P J = 5.2 × 10 -14) and PICALM (rs561655; P M = 7.0 × 10 -11, P J = 1.0 × 10 -10), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.",

author = "Naj, {Adam C.} and Gyungah Jun and Beecham, {Gary W.} and Wang, {Li San} and Vardarajan, {Badri Narayan} and Jacqueline Buros and Gallins, {Paul J.} and Buxbaum, {Joseph D.} and Jarvik, {Gail P.} and Crane, {Paul K.} and Larson, {Eric B.} and Bird, {Thomas D.} and Boeve, {Bradley F.} and Graff-Radford, {Neill R.} and {De Jager}, {Philip L.} and Denis Evans and Schneider, {Julie A.} and Carrasquillo, {Minerva M.} and Nilufer Ertekin-Taner and Younkin, {Steven G.} and Carlos Cruchaga and Kauwe, {John S.K.} and Petra Nowotny and Patricia Kramer and John Hardy and Huentelman, {Matthew J.} and Myers, {Amanda J.} and Barmada, {Michael M.} and Demirci, {F. Yesim} and Baldwin, {Clinton T.} and Green, {Robert C.} and Ekaterina Rogaeva and George-Hyslop, {Peter St} and Arnold, {Steven E.} and Robert Barber and Thomas Beach and Bigio, {Eileen H.} and Bowen, {James D.} and Adam Boxer and Burke, {James R.} and Cairns, {Nigel J.} and Carlson, {Chris S.} and Carney, {Regina M.} and Carroll, {Steven L.} and Chui, {Helena C.} and Clark, {David G.} and Jason Corneveaux and Cotman, {Carl W.} and Cummings, {Jeffrey L.} and Charles Decarli and Dekosky, {Steven T.} and Ramon Diaz-Arrastia and Malcolm Dick and Dickson, {Dennis W.} and Ellis, {William G.} and Faber, {Kelley M.} and Fallon, {Kenneth B.} and Farlow, {Martin R.} and Steven Ferris and Frosch, {Matthew P.} and Galasko, {Douglas R.} and Mary Ganguli and Marla Gearing and Geschwind, {Daniel H.} and Bernardino Ghetti and Gilbert, {John R.} and Sid Gilman and Bruno Giordani and Glass, {Jonathan D.} and Growdon, {John H.} and Hamilton, {Ronald L.} and Harrell, {Lindy E.} and Elizabeth Head and Honig, {Lawrence S.} and Hulette, {Christine M.} and Hyman, {Bradley T.} and Jicha, {Gregory A.} and Jin, {Lee Way} and Nancy Johnson and Jason Karlawish and Anna Karydas and Kaye, {Jeffrey A.} and Ronald Kim and Koo, {Edward H.} and Kowall, {Neil W.} and Lah, {James J.} and Levey, {Allan I.} and Lieberman, {Andrew P.} and Lopez, {Oscar L.} and MacK, {Wendy J.} and Marson, {Daniel C.} and Frank Martiniuk and Mash, {Deborah C.} and Eliezer Masliah and McCormick, {Wayne C.} and McCurry, {Susan M.} and McDavid, {Andrew N.} and McKee, {Ann C.} and Marsel Mesulam and Miller, {Bruce L.} and Miller, {Carol A.} and Miller, {Joshua W.} and Parisi, {Joseph E.} and Perl, {Daniel P.} and Elaine Peskind and Petersen, {Ronald C.} and Poon, {Wayne W.} and Quinn, {Joseph F.} and Rajbhandary, {Ruchita A.} and Murray Raskind and Barry Reisberg and Ringman, {John M.} and Roberson, {Erik D.} and Rosenberg, {Roger N.} and Mary Sano and Schneider, {Lon S.} and William Seeley and Shelanski, {Michael L.} and Slifer, {Michael A.} and Smith, {Charles D.} and Sonnen, {Joshua A.} and Salvatore Spina and Stern, {Robert A.} and Tanzi, {Rudolph E.} and Trojanowski, {John Q.} and Troncoso, {Juan C.} and {Van Deerlin}, {Vivianna M.} and Vinters, {Harry V.} and Vonsattel, {Jean Paul} and Sandra Weintraub and Welsh-Bohmer, {Kathleen A.} and Jennifer Williamson and Woltjer, {Randall L.} and Cantwell, {Laura B.} and Dombroski, {Beth A.} and Duane Beekly and Lunetta, {Kathryn L.} and Martin, {Eden R.} and Kamboh, {M. Ilyas} and Saykin, {Andrew J.} and Reiman, {Eric M.} and Bennett, {David A.} and Morris, {John C.} and Montine, {Thomas J.} and Goate, {Alison M.} and Deborah Blacker and Tsuang, {Debby W.} and Hakon Hakonarson and Kukull, {Walter A.} and Foroud, {Tatiana M.} and Haines, {Jonathan L.} and Richard Mayeux and Pericak-Vance, {Margaret A.} and Farrer, {Lindsay A.} and Schellenberg, {Gerard D.}",

year = "2011",

month = may,

doi = "10.1038/ng.801",

language = "English",

volume = "43",

pages = "436--443",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "5",

}

Naj, AC, Jun, G, Beecham, GW, Wang, LS, Vardarajan, BN, Buros, J, Gallins, PJ, Buxbaum, JD, Jarvik, GP, Crane, PK, Larson, EB, Bird, TD, Boeve, BF, Graff-Radford, NR, De Jager, PL, Evans, D, Schneider, JA, Carrasquillo, MM, Ertekin-Taner, N, Younkin, SG, Cruchaga, C, Kauwe, JSK, Nowotny, P, Kramer, P, Hardy, J, Huentelman, MJ, Myers, AJ, Barmada, MM, Demirci, FY, Baldwin, CT, Green, RC, Rogaeva, E, George-Hyslop, PS, Arnold, SE, Barber, R, Beach, T, Bigio, EH, Bowen, JD, Boxer, A, Burke, JR, Cairns, NJ, Carlson, CS, Carney, RM, Carroll, SL, Chui, HC, Clark, DG, Corneveaux, J, Cotman, CW, Cummings, JL, Decarli, C, Dekosky, ST, Diaz-Arrastia, R, Dick, M, Dickson, DW, Ellis, WG, Faber, KM, Fallon, KB, Farlow, MR, Ferris, S, Frosch, MP, Galasko, DR, Ganguli, M, Gearing, M, Geschwind, DH, Ghetti, B, Gilbert, JR, Gilman, S, Giordani, B, Glass, JD, Growdon, JH, Hamilton, RL, Harrell, LE, Head, E, Honig, LS, Hulette, CM, Hyman, BT, Jicha, GA, Jin, LW, Johnson, N, Karlawish, J, Karydas, A, Kaye, JA, Kim, R, Koo, EH, Kowall, NW, Lah, JJ, Levey, AI, Lieberman, AP, Lopez, OL, MacK, WJ, Marson, DC, Martiniuk, F, Mash, DC, Masliah, E, McCormick, WC, McCurry, SM, McDavid, AN, McKee, AC, Mesulam, M, Miller, BL, Miller, CA, Miller, JW, Parisi, JE, Perl, DP, Peskind, E, Petersen, RC, Poon, WW, Quinn, JF, Rajbhandary, RA, Raskind, M, Reisberg, B, Ringman, JM, Roberson, ED, Rosenberg, RN, Sano, M, Schneider, LS, Seeley, W, Shelanski, ML, Slifer, MA, Smith, CD, Sonnen, JA, Spina, S, Stern, RA, Tanzi, RE, Trojanowski, JQ, Troncoso, JC, Van Deerlin, VM, Vinters, HV, Vonsattel, JP, Weintraub, S, Welsh-Bohmer, KA, Williamson, J, Woltjer, RL, Cantwell, LB, Dombroski, BA, Beekly, D, Lunetta, KL, Martin, ER, Kamboh, MI, Saykin, AJ, Reiman, EM, Bennett, DA, Morris, JC, Montine, TJ, Goate, AM, Blacker, D, Tsuang, DW, Hakonarson, H, Kukull, WA, Foroud, TM, Haines, JL, Mayeux, R, Pericak-Vance, MA, Farrer, LA & Schellenberg, GD 2011, 'Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease', Nature Genetics, vol. 43, no. 5, pp. 436-443. https://doi.org/10.1038/ng.801

TY - JOUR

T1 - Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

AU - Naj, Adam C.

AU - Jun, Gyungah

AU - Beecham, Gary W.

AU - Wang, Li San

AU - Vardarajan, Badri Narayan

AU - Buros, Jacqueline

AU - Gallins, Paul J.

AU - Buxbaum, Joseph D.

AU - Jarvik, Gail P.

AU - Crane, Paul K.

AU - Larson, Eric B.

AU - Bird, Thomas D.

AU - Boeve, Bradley F.

AU - Graff-Radford, Neill R.

AU - De Jager, Philip L.

AU - Evans, Denis

AU - Schneider, Julie A.

AU - Carrasquillo, Minerva M.

AU - Ertekin-Taner, Nilufer

AU - Younkin, Steven G.

AU - Cruchaga, Carlos

AU - Kauwe, John S.K.

AU - Nowotny, Petra

AU - Kramer, Patricia

AU - Hardy, John

AU - Huentelman, Matthew J.

AU - Myers, Amanda J.

AU - Barmada, Michael M.

AU - Demirci, F. Yesim

AU - Baldwin, Clinton T.

AU - Green, Robert C.

AU - Rogaeva, Ekaterina

AU - George-Hyslop, Peter St

AU - Arnold, Steven E.

AU - Barber, Robert

AU - Beach, Thomas

AU - Bigio, Eileen H.

AU - Bowen, James D.

AU - Boxer, Adam

AU - Burke, James R.

AU - Cairns, Nigel J.

AU - Carlson, Chris S.

AU - Carney, Regina M.

AU - Carroll, Steven L.

AU - Chui, Helena C.

AU - Clark, David G.

AU - Corneveaux, Jason

AU - Cotman, Carl W.

AU - Cummings, Jeffrey L.

AU - Decarli, Charles

AU - Dekosky, Steven T.

AU - Diaz-Arrastia, Ramon

AU - Dick, Malcolm

AU - Dickson, Dennis W.

AU - Ellis, William G.

AU - Faber, Kelley M.

AU - Fallon, Kenneth B.

AU - Farlow, Martin R.

AU - Ferris, Steven

AU - Frosch, Matthew P.

AU - Galasko, Douglas R.

AU - Ganguli, Mary

AU - Gearing, Marla

AU - Geschwind, Daniel H.

AU - Ghetti, Bernardino

AU - Gilbert, John R.

AU - Gilman, Sid

AU - Giordani, Bruno

AU - Glass, Jonathan D.

AU - Growdon, John H.

AU - Hamilton, Ronald L.

AU - Harrell, Lindy E.

AU - Head, Elizabeth

AU - Honig, Lawrence S.

AU - Hulette, Christine M.

AU - Hyman, Bradley T.

AU - Jicha, Gregory A.

AU - Jin, Lee Way

AU - Johnson, Nancy

AU - Karlawish, Jason

AU - Karydas, Anna

AU - Kaye, Jeffrey A.

AU - Kim, Ronald

AU - Koo, Edward H.

AU - Kowall, Neil W.

AU - Lah, James J.

AU - Levey, Allan I.

AU - Lieberman, Andrew P.

AU - Lopez, Oscar L.

AU - MacK, Wendy J.

AU - Marson, Daniel C.

AU - Martiniuk, Frank

AU - Mash, Deborah C.

AU - Masliah, Eliezer

AU - McCormick, Wayne C.

AU - McCurry, Susan M.

AU - McDavid, Andrew N.

AU - McKee, Ann C.

AU - Mesulam, Marsel

AU - Miller, Bruce L.

AU - Miller, Carol A.

AU - Miller, Joshua W.

AU - Parisi, Joseph E.

AU - Perl, Daniel P.

AU - Peskind, Elaine

AU - Petersen, Ronald C.

AU - Poon, Wayne W.

AU - Quinn, Joseph F.

AU - Rajbhandary, Ruchita A.

AU - Raskind, Murray

AU - Reisberg, Barry

AU - Ringman, John M.

AU - Roberson, Erik D.

AU - Rosenberg, Roger N.

AU - Sano, Mary

AU - Schneider, Lon S.

AU - Seeley, William

AU - Shelanski, Michael L.

AU - Slifer, Michael A.

AU - Smith, Charles D.

AU - Sonnen, Joshua A.

AU - Spina, Salvatore

AU - Stern, Robert A.

AU - Tanzi, Rudolph E.

AU - Trojanowski, John Q.

AU - Troncoso, Juan C.

AU - Van Deerlin, Vivianna M.

AU - Vinters, Harry V.

AU - Vonsattel, Jean Paul

AU - Weintraub, Sandra

AU - Welsh-Bohmer, Kathleen A.

AU - Williamson, Jennifer

AU - Woltjer, Randall L.

AU - Cantwell, Laura B.

AU - Dombroski, Beth A.

AU - Beekly, Duane

AU - Lunetta, Kathryn L.

AU - Martin, Eden R.

AU - Kamboh, M. Ilyas

AU - Saykin, Andrew J.

AU - Reiman, Eric M.

AU - Bennett, David A.

AU - Morris, John C.

AU - Montine, Thomas J.

AU - Goate, Alison M.

AU - Blacker, Deborah

AU - Tsuang, Debby W.

AU - Hakonarson, Hakon

AU - Kukull, Walter A.

AU - Foroud, Tatiana M.

AU - Haines, Jonathan L.

AU - Mayeux, Richard

AU - Pericak-Vance, Margaret A.

AU - Farrer, Lindsay A.

AU - Schellenberg, Gerard D.

PY - 2011/5

Y1 - 2011/5

N2 - The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P M) = 1.7 × 10 -9, joint analysis P (P J) = 1.7 × 10 -9; stages 1, 2 and 3, P M = 8.2 × 10 -12), CD2AP (rs9349407; stages 1, 2 and 3, P M = 8.6 × 10 -9), EPHA1 (rs11767557; stages 1, 2 and 3, P M = 6.0 × 10 -10) and CD33 (rs3865444; stages 1, 2 and 3, P M = 1.6 × 10 -9). We also replicated previous associations at CR1 (rs6701713; P M = 4.6 × 10 -10, P J = 5.2 × 10 -11), CLU (rs1532278; P M = 8.3 × 10 -8, P J = 1.9 × 10 -8), BIN1 (rs7561528; P M = 4.0 × 10 -14, P J = 5.2 × 10 -14) and PICALM (rs561655; P M = 7.0 × 10 -11, P J = 1.0 × 10 -10), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.

AB - The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P M) = 1.7 × 10 -9, joint analysis P (P J) = 1.7 × 10 -9; stages 1, 2 and 3, P M = 8.2 × 10 -12), CD2AP (rs9349407; stages 1, 2 and 3, P M = 8.6 × 10 -9), EPHA1 (rs11767557; stages 1, 2 and 3, P M = 6.0 × 10 -10) and CD33 (rs3865444; stages 1, 2 and 3, P M = 1.6 × 10 -9). We also replicated previous associations at CR1 (rs6701713; P M = 4.6 × 10 -10, P J = 5.2 × 10 -11), CLU (rs1532278; P M = 8.3 × 10 -8, P J = 1.9 × 10 -8), BIN1 (rs7561528; P M = 4.0 × 10 -14, P J = 5.2 × 10 -14) and PICALM (rs561655; P M = 7.0 × 10 -11, P J = 1.0 × 10 -10), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility.

UR - http://www.scopus.com/inward/record.url?scp=79955464911&partnerID=8YFLogxK

U2 - 10.1038/ng.801

DO - 10.1038/ng.801

M3 - Article

C2 - 21460841

AN - SCOPUS:79955464911

SN - 1061-4036

VL - 43

SP - 436

EP - 443

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -