TY - JOUR
T1 - Community-based gene structure annotation
AU - Schlueter, Shannon D.
AU - Wilkerson, Matthew D.
AU - Huala, Eva
AU - Rhee, Seung Y.
AU - Brendel, Volker
N1 - Funding Information:
This work was supported by NSF Plant Genome Research Grant DBI-0321600 to V.B. and NSF grant number DBI-9978564 to S.Y.R. We thank Michael Lawler and Stephanie Haila, both school science teachers in Iowa, for working with us to develop the gene structure annotation tutorial. Their work was sponsored by an NSF RET grant to Iowa State University. We also thank our colleagues at The Institute for Genomic Research (TIGR) for critical reading and comments.
PY - 2005/1
Y1 - 2005/1
N2 - Uncertainty and inconsistency of gene structure annotation remain limitations on research in the genome era, frustrating both biologists and bioinformaticians, who have to sort out annotation errors for their genes of interest or to generate trustworthy datasets for algorithmic development. It is unrealistic to hope for better software solutions in the near future that would solve all the problems. The issue is all the more urgent with more species being sequenced and analyzed by comparative genomics - erroneous annotations could easily propagate, whereas correct annotations in one species will greatly facilitate annotation of novel genomes. We propose a dynamic, economically feasible solution to the annotation predicament: broad-based, web-technology-enabled community annotation, a prototype of which is now in use for Arabidopsis.
AB - Uncertainty and inconsistency of gene structure annotation remain limitations on research in the genome era, frustrating both biologists and bioinformaticians, who have to sort out annotation errors for their genes of interest or to generate trustworthy datasets for algorithmic development. It is unrealistic to hope for better software solutions in the near future that would solve all the problems. The issue is all the more urgent with more species being sequenced and analyzed by comparative genomics - erroneous annotations could easily propagate, whereas correct annotations in one species will greatly facilitate annotation of novel genomes. We propose a dynamic, economically feasible solution to the annotation predicament: broad-based, web-technology-enabled community annotation, a prototype of which is now in use for Arabidopsis.
UR - http://www.scopus.com/inward/record.url?scp=11844251278&partnerID=8YFLogxK
U2 - 10.1016/j.tplants.2004.11.002
DO - 10.1016/j.tplants.2004.11.002
M3 - Article
AN - SCOPUS:11844251278
SN - 1360-1385
VL - 10
SP - 9
EP - 14
JO - Trends in Plant Science
JF - Trends in Plant Science
IS - 1
ER -