TY - JOUR
T1 - Comparison of thallium-201 single-photon emission computed tomographic scintigraphy with intravenous dipyridamole and arm exercise
AU - Grover-McKay, Maleah
AU - Milne, Norah
AU - Atwood, J. Edwin
AU - Lyons, Kenneth P.
N1 - Funding Information:
From the Cardiology Section and the Department of Nuclear Long Beach Veterans Administration Medical Center. Supported in part by grants from the VA Research Advisory Group, University of California, Irvine-AHA Endowment Research Proposal, and by a University of California, Irvine Faculty Research Grant. Received for publication July 8, 1993; accepted Oct. 15, 1993. Reprint requests: M&ah Grover-McKay, MD, Department Medicine, University of Iowa Hospital, City, IA 52242. Copyright @ 1994 by Mosby-Year Book, Inc. 0002-8703/94/$3.00 + 0 4/l/53790
PY - 1994/6
Y1 - 1994/6
N2 - In patients who cannot perform treadmill exercise, both intravenous dipyridamole and arm exercise have been used with thallium-201 scintigraphy to detect significant coronary artery disease. However, no study has directly evaluated the results of intravenous dipyridamole and arm exercise thallium scintigraphy as compared with coronary angiography. It was the purpose of this study to compare intravenous dipyridamole and arm exercise thallium-201 single-photon emission computed tomographic (SPECT) scintigraphy for detection of significant coronary artery disease in patients who could not perform treadmill exercise. Data are presented for both intravenous dipyridamole and arm exercise thallium-201 SPECT scintigraphy in 18 men who could not perform treadmill exercise, and results are compared with those of coronary angiography. Ten of 11 (91%) patients with significant coronary artery disease were identified correctly, and the results of intravenous dipyridamole and arm exercise thallium scintigraphy were comparable. In patients without significant coronary artery disease, intravenous dipyridamole thallium images were interpreted correctly. However, initial arm exercise thallium images demonstrated a fixed inferior wall defect in two of seven patients without significant coronary artery disease. Images in one of these patients could not be retrieved from tape for further analysis. Review of the images in the other patient demonstrated relatively high background radioactivity, and when the images were displayed without background subtraction, the inferior wall was correctly interpreted as normal. We conclude that results of intravenous dipyridamole and arm exercise thallium-201 SPECT scintigraphy are comparable.
AB - In patients who cannot perform treadmill exercise, both intravenous dipyridamole and arm exercise have been used with thallium-201 scintigraphy to detect significant coronary artery disease. However, no study has directly evaluated the results of intravenous dipyridamole and arm exercise thallium scintigraphy as compared with coronary angiography. It was the purpose of this study to compare intravenous dipyridamole and arm exercise thallium-201 single-photon emission computed tomographic (SPECT) scintigraphy for detection of significant coronary artery disease in patients who could not perform treadmill exercise. Data are presented for both intravenous dipyridamole and arm exercise thallium-201 SPECT scintigraphy in 18 men who could not perform treadmill exercise, and results are compared with those of coronary angiography. Ten of 11 (91%) patients with significant coronary artery disease were identified correctly, and the results of intravenous dipyridamole and arm exercise thallium scintigraphy were comparable. In patients without significant coronary artery disease, intravenous dipyridamole thallium images were interpreted correctly. However, initial arm exercise thallium images demonstrated a fixed inferior wall defect in two of seven patients without significant coronary artery disease. Images in one of these patients could not be retrieved from tape for further analysis. Review of the images in the other patient demonstrated relatively high background radioactivity, and when the images were displayed without background subtraction, the inferior wall was correctly interpreted as normal. We conclude that results of intravenous dipyridamole and arm exercise thallium-201 SPECT scintigraphy are comparable.
UR - http://www.scopus.com/inward/record.url?scp=0028244798&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(94)90379-4
DO - 10.1016/0002-8703(94)90379-4
M3 - Article
C2 - 8197977
AN - SCOPUS:0028244798
SN - 0002-8703
VL - 127
SP - 1516
EP - 1520
JO - American Heart Journal
JF - American Heart Journal
IS - 6
ER -