Complex systems analysis: A tool for shock research

Timothy G. Buchman*, J. Perren Cobb, Alan S. Lapedes, Thomas B. Kepler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


For the past century, students of shock have focused research efforts to illuminate specific mechanisms that cause, or fail as a consequence of, circulatory collapse. Although clinical strategies aimed at supporting or restoring individual organ systems have proven effective, many patients succumb to more generalized multiple organ system failure. We suggest that general biological systems failure cannot be interpreted through reliance on reductionist science. We propose that complex systems analysis is an essential tool for shock research and we evaluate its application to genomic technologies.

Original languageEnglish
Pages (from-to)248-251
Number of pages4
Issue number4
StatePublished - Oct 2001
Externally publishedYes


  • Complex systems
  • MODS
  • Reductionism
  • Shock


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