TY - JOUR
T1 - Concordance between the CC chemokine receptor 5 genetic determinants that alter risks of transmission and disease progression in children exposed perinatally to human immunodeficiency virus
AU - Mangano, Andrea
AU - Gonzalez, Enrique
AU - Dhanda, Rahul
AU - Catano, Gabriel
AU - Bamshad, Mike
AU - Bock, Amanda
AU - Duggirala, Ravindranath
AU - Williams, Ken
AU - Mummidi, Srinivas
AU - Clark, Robert A.
AU - Ahuja, Seema S.
AU - Dolan, Matthew J.
AU - Bologna, Rosa
AU - Sen, Luisa
AU - Ahuja, Sunil K.
N1 - Funding Information:
Financial support: Department of Veterans Affairs Merit Award, National Institutes of Health (AI-43279 and AI-4632) to S.K.A.; a minority supplement grant from the National Institutes of Health to E.G.; Consejo Nacional de Investigaciones Científicas y Técnicas (0494), Agencia Nacional Científica y Tec-nológicas (2167), and Foundation “Alberto J. Roemmers” (work conducted in Argentina). S.K.A. is a recipient of the Elizabeth Glaser Scientist Award. a A.M. and E.G. contributed equally to this paper.
PY - 2001/6/1
Y1 - 2001/6/1
N2 - If CC chemokine receptor 5 (CCR5)-dependent mechanisms at the time of initial virus exposure are important determinants of virus entry and disease outcome, then the polymorphisms in CCR5 that influence risk of transmission and disease progression should be similar; this hypothesis was tested in a cohort of 649 Argentinean children exposed perinatally to human immunodeficiency virus type 1 (HIV-1). Two lines of evidence support this hypothesis. First, CCR5 haplotype pairs associated with enhanced risk of transmission were the chief predictors of a faster disease course. Second, some of the haplotype pairs associated with altered rates of transmission and disease progression in children were similar to those that we previously found influenced outcome in European American adults. This concordance suggests that CCR5 haplotypes may serve as genetic rheostats that influence events occurring shortly after initial virus exposure, dictating not only virus entry but, by extension, also the extent of early viral replication.
AB - If CC chemokine receptor 5 (CCR5)-dependent mechanisms at the time of initial virus exposure are important determinants of virus entry and disease outcome, then the polymorphisms in CCR5 that influence risk of transmission and disease progression should be similar; this hypothesis was tested in a cohort of 649 Argentinean children exposed perinatally to human immunodeficiency virus type 1 (HIV-1). Two lines of evidence support this hypothesis. First, CCR5 haplotype pairs associated with enhanced risk of transmission were the chief predictors of a faster disease course. Second, some of the haplotype pairs associated with altered rates of transmission and disease progression in children were similar to those that we previously found influenced outcome in European American adults. This concordance suggests that CCR5 haplotypes may serve as genetic rheostats that influence events occurring shortly after initial virus exposure, dictating not only virus entry but, by extension, also the extent of early viral replication.
UR - http://www.scopus.com/inward/record.url?scp=0035370348&partnerID=8YFLogxK
U2 - 10.1086/320705
DO - 10.1086/320705
M3 - Article
C2 - 11335892
AN - SCOPUS:0035370348
SN - 0022-1899
VL - 183
SP - 1574
EP - 1585
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -