Concurrent infections in acute febrile illness patients in Egypt

Tina M. Parker, Clinton K. Murray, Allen L. Richards, Ahmed Samir, Tharwat Ismail, Moustafa Abdel Fadeel, Ju Jiang, Momtaz O. Wasfy, Guillermo Pimentel

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

We report the occurrence of concurrent infections with multiple acute febrile illness (AFI) pathogens during an ongoing prospective laboratory-based surveillance in four infectious disease hospitals in urban and rural areas of Egypt from June 2005 to August 2006. Patients were screened for Leptospira, Rickettsia typhi, Brucella, or Salmonella enterica serogroup Typhi by various methods including serology, culture, and PCR. One hundred eighty-seven of 1,510 patients (12.4%) evaluated had supporting evidence for the presence of coinfections; 20 (1%) of these patients had 2 or more pathogens based upon confirmatory 4-fold rise in antibody titer, culture, and/or PCR. Most coinfected patients lived or worked in rural agricultural areas. The high coinfection rates suggest that defining the etiologies of AFI is imperative in guiding proper disease treatment, prevention, and control strategies in Egypt.

Original languageEnglish
Pages (from-to)390-392
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume77
Issue number2
DOIs
StatePublished - Aug 2007
Externally publishedYes

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