Congruity between Mental Stress-Induced and Adenosine-Induced Myocardial Ischemia Assessed Using SPECT in Heart Failure Patients

Stephen S. Gottlieb; Vasken Dilsizian; Andrew J. Wawrzyniak; Mark Smith; Kristie M. Harris; Kerry Whittaker; David Krantz

doi:10.1016/j.cardfail.2014.06.056

Congruity between Mental Stress-Induced and Adenosine-Induced Myocardial Ischemia Assessed Using SPECT in Heart Failure Patients

Stephen S. Gottlieb, Vasken Dilsizian, Andrew J. Wawrzyniak, Mark Smith, Kristie M. Harris, Kerry Whittaker, David Krantz

Medical & Clinical Psychology

Research output: Contribution to journal › Article

Abstract

Background: Mental stress can trigger myocardial ischemia in a substantial percentage of patients with coronary artery disease, but the prevalence of mental stress induced ischemia is unknown in patients with heart failure. Increased neuroendocrine activation in these patients could significantly impact the effects of mental stress on coronary blood flow and myocardial perfusion. Objective: The purpose of the current study was to characterize mental stress-induced versus adenosine-induced changes in myocardial ischemia in heart failure patients with reduced LV function using singlephoton emission computed tomography (SPECT) to objectively and precisely quantify segment-level myocardial perfusion. Methods: Entry criteria included a history of heart failure>3 months, ejection fraction

Original language	American English
Pages (from-to)	S18
Journal	Journal of Cardiac Failure
Volume	20
Issue number	8
DOIs	https://doi.org/10.1016/j.cardfail.2014.06.056
State	Published - Aug 2014

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10.1016/j.cardfail.2014.06.056

Cite this

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title = "Congruity between Mental Stress-Induced and Adenosine-Induced Myocardial Ischemia Assessed Using SPECT in Heart Failure Patients",

abstract = "Background: Mental stress can trigger myocardial ischemia in a substantial percentage of patients with coronary artery disease, but the prevalence of mental stress induced ischemia is unknown in patients with heart failure. Increased neuroendocrine activation in these patients could significantly impact the effects of mental stress on coronary blood flow and myocardial perfusion. Objective: The purpose of the current study was to characterize mental stress-induced versus adenosine-induced changes in myocardial ischemia in heart failure patients with reduced LV function using singlephoton emission computed tomography (SPECT) to objectively and precisely quantify segment-level myocardial perfusion. Methods: Entry criteria included a history of heart failure>3 months, ejection fraction",

author = "Gottlieb, {Stephen S.} and Vasken Dilsizian and Wawrzyniak, {Andrew J.} and Mark Smith and Harris, {Kristie M.} and Kerry Whittaker and David Krantz",

year = "2014",

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doi = "10.1016/j.cardfail.2014.06.056",

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journal = "Journal of Cardiac Failure",

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AU - Gottlieb, Stephen S.

AU - Dilsizian, Vasken

AU - Wawrzyniak, Andrew J.

AU - Smith, Mark

AU - Harris, Kristie M.

AU - Whittaker, Kerry

AU - Krantz, David

PY - 2014/8

Y1 - 2014/8

N2 - Background: Mental stress can trigger myocardial ischemia in a substantial percentage of patients with coronary artery disease, but the prevalence of mental stress induced ischemia is unknown in patients with heart failure. Increased neuroendocrine activation in these patients could significantly impact the effects of mental stress on coronary blood flow and myocardial perfusion. Objective: The purpose of the current study was to characterize mental stress-induced versus adenosine-induced changes in myocardial ischemia in heart failure patients with reduced LV function using singlephoton emission computed tomography (SPECT) to objectively and precisely quantify segment-level myocardial perfusion. Methods: Entry criteria included a history of heart failure>3 months, ejection fraction

AB - Background: Mental stress can trigger myocardial ischemia in a substantial percentage of patients with coronary artery disease, but the prevalence of mental stress induced ischemia is unknown in patients with heart failure. Increased neuroendocrine activation in these patients could significantly impact the effects of mental stress on coronary blood flow and myocardial perfusion. Objective: The purpose of the current study was to characterize mental stress-induced versus adenosine-induced changes in myocardial ischemia in heart failure patients with reduced LV function using singlephoton emission computed tomography (SPECT) to objectively and precisely quantify segment-level myocardial perfusion. Methods: Entry criteria included a history of heart failure>3 months, ejection fraction

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