TY - JOUR
T1 - Connecting combat-related mild traumatic brain injury with posttraumatic stress disorder symptoms through brain imaging
AU - Costanzo, Michelle E.
AU - Chou, Yi Yu
AU - Leaman, Suzanne
AU - Pham, Dzung L.
AU - Keyser, David
AU - Nathan, Dominic E.
AU - Coughlin, Mary
AU - Rapp, Paul
AU - Roy, Michael J.
N1 - Funding Information:
This work was funded by the Department of Defense the Center for Neuroscience and Regenerative Medicine 300601 8.01 60855510005 . Any opinions or assertions expressed are solely those of the authors and do not necessarily represent those of Uniformed Services University, the US Army, US Navy, Department of Defense, or the US Government. Thank you to Mariam Masheeb, Julie McEntee, Rochelle Ndiongue, Carol Roos, Patricia Taylor and Joanna Vivalda for their administrative and facilitative contributions.
PY - 2014/8/8
Y1 - 2014/8/8
N2 - Mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) may share common symptom and neuropsychological profiles in military service members (SMs) following deployment; while a connection between the two conditions is plausible, the relationship between them has been difficult to discern. The intent of this report is to enhance our understanding of the relationship between findings on structural and functional brain imaging and symptoms of PTSD. Within a cohort of SMs who did not meet criteria for PTSD but were willing to complete a comprehensive assessment within 2 months of their return from combat deployment, we conducted a nested case-control analysis comparing those with combat-related mTBI to age/gender-matched controls with diffusion tensor imaging, resting state functional magnetic resonance imaging and a range of psychological measures. We report degraded white matter integrity in those with a history of combat mTBI, and a positive correlation between the white matter microstructure and default mode network (DMN) connectivity. Higher clinician-administered and self-reported subthreshold PTSD symptoms were reported in those with combat mTBI. Our findings offer a potential mechanism through which mTBI may alter brain function, and in turn, contribute to PTSD symptoms.
AB - Mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) may share common symptom and neuropsychological profiles in military service members (SMs) following deployment; while a connection between the two conditions is plausible, the relationship between them has been difficult to discern. The intent of this report is to enhance our understanding of the relationship between findings on structural and functional brain imaging and symptoms of PTSD. Within a cohort of SMs who did not meet criteria for PTSD but were willing to complete a comprehensive assessment within 2 months of their return from combat deployment, we conducted a nested case-control analysis comparing those with combat-related mTBI to age/gender-matched controls with diffusion tensor imaging, resting state functional magnetic resonance imaging and a range of psychological measures. We report degraded white matter integrity in those with a history of combat mTBI, and a positive correlation between the white matter microstructure and default mode network (DMN) connectivity. Higher clinician-administered and self-reported subthreshold PTSD symptoms were reported in those with combat mTBI. Our findings offer a potential mechanism through which mTBI may alter brain function, and in turn, contribute to PTSD symptoms.
KW - Combat-related posttraumatic stress
KW - Default mode network
KW - Diffusion tensor imaging
KW - Functional magnetic resonance imaging
KW - Mild traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=84903433585&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2014.05.054
DO - 10.1016/j.neulet.2014.05.054
M3 - Article
C2 - 24907686
AN - SCOPUS:84903433585
SN - 0304-3940
VL - 577
SP - 11
EP - 15
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -