TY - JOUR
T1 - ConsensusClusterPlus
T2 - A class discovery tool with confidence assessments and item tracking
AU - Wilkerson, Matthew D.
AU - Hayes, D. Neil
N1 - Funding Information:
Funding: National Cancer Institute (NCI) F32CA142039 to M.D.W., Thomas G. Labrecque Foundation through Joan’s Legacy Foundation to D.N.H., and National Institutes of Health (NIH) U24CA126554. The content is solely the responsibility of the authors and does not necessarily represent the official views of NCI or NIH.
PY - 2010/4/28
Y1 - 2010/4/28
N2 - Summary: Unsupervised class discovery is a highly useful technique in cancer research, where intrinsic groups sharing biological characteristics may exist but are unknown. The consensus clustering (CC) method provides quantitative and visual stability evidence for estimating the number of unsupervised classes in a dataset. ConsensusClusterPlus implements the CC method in R and extends it with new functionality and visualizations including item tracking, item-consensus and cluster-consensus plots. These new features provide users with detailed information that enable more specific decisions in unsupervised class discovery. Availability: ConsensusClusterPlus is open source software, written in R, under GPL-2, and available through the Bioconductor project (http://www.bioconductor.org/). Contact: [email protected]. Supplementary Information: Supplementary data are available at Bioinformatics online.
AB - Summary: Unsupervised class discovery is a highly useful technique in cancer research, where intrinsic groups sharing biological characteristics may exist but are unknown. The consensus clustering (CC) method provides quantitative and visual stability evidence for estimating the number of unsupervised classes in a dataset. ConsensusClusterPlus implements the CC method in R and extends it with new functionality and visualizations including item tracking, item-consensus and cluster-consensus plots. These new features provide users with detailed information that enable more specific decisions in unsupervised class discovery. Availability: ConsensusClusterPlus is open source software, written in R, under GPL-2, and available through the Bioconductor project (http://www.bioconductor.org/). Contact: [email protected]. Supplementary Information: Supplementary data are available at Bioinformatics online.
UR - http://www.scopus.com/inward/record.url?scp=77954182362&partnerID=8YFLogxK
U2 - 10.1093/bioinformatics/btq170
DO - 10.1093/bioinformatics/btq170
M3 - Article
C2 - 20427518
AN - SCOPUS:77954182362
SN - 1367-4803
VL - 26
SP - 1572
EP - 1573
JO - Bioinformatics
JF - Bioinformatics
IS - 12
M1 - btq170
ER -