Conservation of protein kinase a catalytic subunit sequences in the schistosome pathogens of humans

Brett E. Swierczewski, Stephen J. Davies*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


cAMP-dependent protein kinases (PKAs) are central mediators of cAMP signaling in eukaryotic cells. Previously we identified a cDNA which encodes for a PKA catalytic subunit (PKA-C) in Schistosoma mansoni (SmPKA-C) that is required for adult schistosome viability in vitro. As such, SmPKA-C could potentially represent a novel schistosome chemotherapeutic target. Here we sought to identify PKA-C subunit orthologues in the other medically important schistosome species, Schistosoma haematobium and Schistosoma japonicum, to determine the degree to which this potential target is conserved and could therefore be exploited for the treatment of all forms of schistosomiasis. We report the identification of PKA-C subunit orthologues in S. haematobium and S. japonicum (ShPKA-C and SjPKA-C, respectively) and show that PKA-C orthologues are highly conserved in the Schistosoma, with over 99% amino acid sequence identity shared among the three human pathogens we examined. Furthermore, we show that the recently published Schistosoma mansoni and S. japonicum genomes contain sequences encoding for several putative PKA substrates with homology to those found in Homo sapiens, Caenorhabditis elegans, and Saccharomyces cerevisiae.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalExperimental Parasitology
Issue number2
StatePublished - Jun 2010


  • CAMP-dependent protein kinase
  • Schistosoma haematobium
  • Schistosoma japonicum


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